Histological alterations in gills and liver of rainbow trout ( Oncorhynchus mykiss ) after exposure to the antibiotic oxytetracycline

Highlights • Exposure to OTC caused damage to gill and liver tissues. • The lesions were moderate pathological importance, non-specific and reversible. • Some changes represent adaptive alterations. • OTC may interfere with different biochemical pathways and metabolic processes.

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2017-07, Vol.53, p.164-176
Main Authors: Rodrigues, S, Antunes, S.C, Nunes, B, Correia, A.T
Format: Article
Language:English
Subjects:
Acute and chronic exposures
Animals
Anti-Bacterial Agents - toxicity
Antibiotics
Chronic exposure
Disorders
Emergency
Epithelial cells
Exposure
Fish
Gills
Gills - drug effects
Gills - pathology
Gills and liver histopathology
Hemorrhage
Hepatocytes
Histology
Hyperplasia
Hypertrophy
Infiltration
Inflammation
Lamellae
Lesions
Leukocytes
Liver
Liver - drug effects
Liver - pathology
Metabolic disorders
Molecular chains
Nuclei
Oncorhynchus mykiss
Oxytetracycline
Oxytetracycline - toxicity
Pathology
Rainbow trout
Salmon
Trout
Water Pollutants, Chemical - toxicity
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Description
Summary:Highlights • Exposure to OTC caused damage to gill and liver tissues. • The lesions were moderate pathological importance, non-specific and reversible. • Some changes represent adaptive alterations. • OTC may interfere with different biochemical pathways and metabolic processes.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2017.05.012