Metallic nanoparticles to eradicate bacterial bone infection

Abstract Treatment of osteomyelitis by conventional antibiotics has proven to be challenging due to limited accessibility to this unique location. Inorganic routes against bacterial infection have been reported for external and topical applications, however in vivo application of these antimicrobial...

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Bibliographic Details
Published in:Nanomedicine 2017-10, Vol.13 (7), p.2241-2250
Main Authors: Qadri, Shahnaz, Haik, Yousef, Mensah-Brown, Eric, Bashir, Ghada, Fernandez-Cabezudo, Maria J, al-Ramadi, Basel K
Format: Article
Language:English
Subjects:
Ag-Cu-B
Animal model
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Biofilms - drug effects
Bone and Bones - microbiology
Boron - administration & dosage
Boron - therapeutic use
Copper - administration & dosage
Copper - therapeutic use
Female
In vivo
Internal Medicine
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - therapeutic use
Mice
Mice, Inbred BALB C
Nanoparticles
Osteomyelitis
Osteomyelitis - drug therapy
Osteomyelitis - microbiology
Silver - administration & dosage
Silver - therapeutic use
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcus aureus - drug effects
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Summary:Abstract Treatment of osteomyelitis by conventional antibiotics has proven to be challenging due to limited accessibility to this unique location. Inorganic routes against bacterial infection have been reported for external and topical applications, however in vivo application of these antimicrobials has not been fully explored. Targeted delivery of metallic nanoparticles with inherent antimicrobial activity represents an alternative means of overcoming the challenges posed by multidrug-resistant bacteria and may potentially reduce overall morbidity. In this study we utilized silver-copper-boron composite nanoparticles in an attempt to eradicate S. aureus bone infection in mice. Our results demonstrate effective response when nanoparticles were administered via i.v. or i.m route (1 mg/kg dose) where 99% of bacteria were eliminated in an induced osteomyelitis mouse model. The 1 mg/kg dose was neither toxic nor produced any adverse immune response, hence it is believed that metallic nanoparticles present an alternative to antibiotics for the treatment of bone infection.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2017.05.013