Usefulness of ischemia-modified albumin in predicting oxidative stress in patients with vitiligo

To investigate the emphasis of oxidative stress in the pathogenesis of vitiligo through an evaluation of ischemia-modified albumin (IMA). IMA was of higher statistical significance in patients than in the control group (IMA: 0.57 ± 0.2 vs 0.52 ± 0.2 ΔABSU; p < 0.0001). IMA (p < 0.0001; OR: 8.9...

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Bibliographic Details
Published in:Biomarkers in medicine 2017-05, Vol.11 (6), p.439-449
Main Authors: Ata, Hatice, Kocab y k, Murat, Gönül, Müzeyyen, Öztürk, Yasin, Kavutçu, Mustafa
Format: Article
Language:English
Subjects:
Acids
Adult
Age
Aged
Albumin
antioxidative system
balance
bioinformatics
Biomarkers
Biomarkers - blood
contributing factors
Disease
enzyme activity
Enzymes
Female
Females
Gender
Humans
IMA
Ischemia
Lifestyles
Male
Males
Middle Aged
Oxidative Stress
Prognosis
Risk factors
Serum Albumin, Human
usefulness
Vitiligo
Vitiligo - blood
Vitiligo - diagnosis
Vitiligo - metabolism
Young Adult
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Summary:To investigate the emphasis of oxidative stress in the pathogenesis of vitiligo through an evaluation of ischemia-modified albumin (IMA). IMA was of higher statistical significance in patients than in the control group (IMA: 0.57 ± 0.2 vs 0.52 ± 0.2 ΔABSU; p < 0.0001). IMA (p < 0.0001; OR: 8.9; 95% CI = 3.1-26.1) was found as an independent predictor of oxidative stress. Increases in affected body surface area and age were found to be independent risk factors for IMA. The sensitivity, specificity and positive and negative predictive values and capacity of IMA were higher than other studied biomarkers. IMA can be detected in the condition of oxidative stress in vitiligo; it has great potential as a biomarker of said condition, when compared with other studied biomarkers.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2016-0259