IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway

• Published in: Metabolic brain disease 2017-10, Vol.32 (5), p.1571-1583
• Main Authors: Roomruangwong, Chutima, Kanchanatawan, Buranee, Sirivichayakul, Sunee, Anderson, George, Carvalho, André F., Duleu, Sebastien, Geffard, Michel, Maes, Michael
• Format: Article
• Language: English
• Subjects: Adducts; Adult; Autoimmunity - immunology; Bacteria; Bacterial Translocation - immunology; Biochemistry; Biomarkers; Biomedical and Life Sciences; Biomedicine; C-reactive protein; Catabolites; Citrobacter; Cytokines - metabolism; Depression, Postpartum - immunology; Depression, Postpartum - psychology; Depressive Disorder, Major - epidemiology; Depressive Disorder, Major - immunology; Depressive Disorder, Major - psychology; Epitopes; Epitopes - immunology; Female; Gram-negative bacteria; Gram-Negative Bacteria - immunology; Humans; Immunoglobulin A; Immunoglobulin M; Immunoglobulin M - immunology; Inflammation; Inflammation - immunology; Klebsiella; Kynurenine - metabolism; Malondialdehyde; Mental depression; Metabolic Diseases; Metabolic Networks and Pathways; Neurology; Neurosciences; Nitric oxide; Nitric Oxide - metabolism; Oncology; Original Article; Pregnancy; Pregnancy - immunology; Prenatal depression; Pseudomonas putida; Small intestine; Translocation; Tryptophan; Tryptophan - metabolism; Young Adult
• ISSN: 0885-7490; 1573-7365
• DOI: 10.1007/s11011-017-0040-2

Immunoglubulin (Ig)M responses directed to oxidative specific epitopes (OSEs) and nitric oxide (NO)-adducts are significantly associated with major depression and physio-somatic symptoms. End of term serum IgM responses to OSEs and NO-adducts were assayed in pregnant women with ( n  = 24) and without prenatal depression ( n  = 25) as well as in 24 non-pregnant women. Associations of IgM/IgA responses to Gram-negative gut commensal bacteria (leaky gut index) and IgA/IgM responses to tryptophan catabolites (TRYCATs) were analyzed. IgM responses to OSEs, but not NO-adducts, were significantly reduced at the end of term. There were no significant associations between IgM responses to OSEs and perinatal depression, whilst IgM responses to NO-adducts, especially NO-cysteinyl, were significantly associated with a lifetime major depression. IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii , Klebsiella pneumoniae and Citrobacter koseri . IgM responses to NO-adducts and OSEs, especially malondialdehyde and myristic acid, and C-reactive protein (CRP) were inversely associated with TRYCAT pathway activity, whilst a lifetime depression and Pseudomonas putida were positively associated. The attenuation of natural IgM-mediated responses to OSEs at the end of term may indicate lowered activity of this part of the compensatory (anti-)inflammatory reflex system and may be partly explained by lowered bacterial translocation. Increased IgM responses to NO-cysteinyl is a biomarker of lifetime depression and may be induced by bacterial translocation. Natural IgM-mediated autoimmune responses, increased nitrosylation and higher CRP levels may have negative regulatory effects on the TRYCAT pathway.