Targeting epithelial-mesenchymal transition: Metal organic network nano-complexes for preventing tumor metastasis

Abstract Tumor metastasis is the leading cause of death in cancer patients, and epithelial-mesenchymal transition (EMT) is an essential step in tumor metastasis. Unfortunately, during the chemotherapy, EMT could be induced under the selective pressure of clinical cytotoxic drugs. Here, to solve this...

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Bibliographic Details
Published in:Biomaterials 2017-09, Vol.139, p.116-126
Main Authors: Fan, Jin-Xuan, Zheng, Di-Wei, Rong, Lei, Zhu, Jing-Yi, Hong, Sheng, Li, Cao, Xu, Zu-Shun, Cheng, Si-Xue, Zhang, Xian-Zheng
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Anti-cancer therapy
Anticarcinogenic Agents - chemical synthesis
Anticarcinogenic Agents - pharmacology
Anticarcinogenic Agents - therapeutic use
Catechin - analogs & derivatives
Catechin - chemical synthesis
Catechin - pharmacology
Catechin - therapeutic use
Cell Line, Tumor
Cell Movement
Dentistry
Doxorubicin - chemistry
Drug Delivery Systems
Drug Resistance, Neoplasm
Epithelial-mesenchymal transition
Epithelial-Mesenchymal Transition - drug effects
Female
Gene Expression Regulation, Neoplastic
Humans
Iron - chemistry
Metal Nanoparticles - chemistry
Metal Nanoparticles - therapeutic use
Mice
Mice, Inbred BALB C
Mice, Nude
Multidrug resistance
Nano-medicine
Neoplasm Metastasis - prevention & control
Tumor metastasis
Xenograft Model Antitumor Assays
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Summary:Abstract Tumor metastasis is the leading cause of death in cancer patients, and epithelial-mesenchymal transition (EMT) is an essential step in tumor metastasis. Unfortunately, during the chemotherapy, EMT could be induced under the selective pressure of clinical cytotoxic drugs. Here, to solve this problem, we have synthesized multi-functional epigallocatechin gallate/iron nano-complexes (EIN) as a versatile coating material to improve conventional therapies. In vitro studies showed that this strategy could eliminate EMT-type cancer cells. Mechanism studies also revealed that EIN was able to down-regulate the downstream expression of metastasis-associated factors, decrease the migration ability of cancer cells and prevent cancer cells from gaining drug resistance. In vivo investigation revealed that EIN had superior ability to enhance the therapeutic effect of conventional nanomedicines and inhibit the EMT process. Our study indicates the promising use of EIN to make up for the deficiencies of chemotherapy may provide insights into systematic cancer therapy to overcome tumor metastasis and drug resistance.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2017.06.007