Leptomycin B attenuates neuronal death via PKA- and PP2B-mediated ERK1/2 activation in the rat hippocampus following status epilepticus

Highlights • LMB attenuated SE-induced neuronal death with increased PKA, PP2B and ERK phosphorylations. • H-89 diminished the neuroprotective effect of LMB accompanied by reduced EKR phosphorylation. • CsA enhanced the neuroprotective effect of LMB with increased EKR phosphorylation. • Co-treatment...

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Bibliographic Details
Published in:Brain research 2017-09, Vol.1670, p.14-23
Main Authors: Min, Su-Ji, Hyun, Hye-Won, Kang, Tae-Cheon
Format: Article
Language:English
Subjects:
Animals
Calcineurin
Calcineurin - metabolism
Cell Death - drug effects
Cyclic AMP-Dependent Protein Kinases - metabolism
Cyclosporin A
Cyclosporine - pharmacology
Disease Models, Animal
Epilepsy
Fatty Acids, Unsaturated - pharmacology
H-89
Hippocampus - drug effects
Hippocampus - enzymology
Hippocampus - pathology
Isoquinolines - pharmacology
Male
MAP Kinase Signaling System - drug effects
Neurology
Neurons - drug effects
Neurons - enzymology
Neurons - pathology
Neuroprotective Agents - pharmacology
Phosphorylation - drug effects
Rats
Rats, Sprague-Dawley
Seizure
Seizures - chemically induced
Status Epilepticus - enzymology
Status Epilepticus - metabolism
Status Epilepticus - pathology
Status Epilepticus - prevention & control
Sulfonamides - pharmacology
Temporal Lobe - metabolism
U0126
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Summary:Highlights • LMB attenuated SE-induced neuronal death with increased PKA, PP2B and ERK phosphorylations. • H-89 diminished the neuroprotective effect of LMB accompanied by reduced EKR phosphorylation. • CsA enhanced the neuroprotective effect of LMB with increased EKR phosphorylation. • Co-treatment of U0126 with LMB aggravated SE-induced neuronal death more than LMB. • LMB protected neurons from SE via PKA- and PP2B-mediated ERK activation.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2017.06.002