Exploring the Boundaries of “Practical”: De Novo Syntheses of Complex Natural Product-Based Drug Candidates

This review examines the state of the art in synthesis as it relates to the building of complex architectures on scales sufficient to drive human drug trials. We focus on the relatively few instances in which a natural-product-based development candidate has been manufactured de novo, rather than se...

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Bibliographic Details
Published in:Chemical reviews 2017-09, Vol.117 (18), p.11994-12051
Main Authors: Allred, Tyler K, Manoni, Francesco, Harran, Patrick G
Format: Article
Language:English
Subjects:
Biological Products - chemical synthesis
Biological Products - chemistry
Clinical trials
Drug Design
Drugs
Humans
Molecular Structure
Natural products
Pharmaceutical Preparations - chemical synthesis
Pharmaceutical Preparations - chemistry
State-of-the-art reviews
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Summary:This review examines the state of the art in synthesis as it relates to the building of complex architectures on scales sufficient to drive human drug trials. We focus on the relatively few instances in which a natural-product-based development candidate has been manufactured de novo, rather than semisynthetically. This summary provides a view of the strengths and weaknesses of current technologies, provides perspective on what one might consider a practical contribution, and hints at directions the field might take in the future.
ISSN:0009-2665
1520-6890
DOI:10.1021/acs.chemrev.7b00126