Synergistic activity of ceftazidime-avibactam and aztreonam against serine and metallo β-lactamase-producing Gram negative pathogens

Abstract This study assessed the in vitro synergy between ceftazidime, aztreonam, and ceftazidime-avibactam against serine and metallo-β-lactamase (MBL)-producing pathogens via the Etest MIC:MIC ratio and Agar-Etest synergy methods. The combination of aztreonam and ceftazidime-avibactam was synergis...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2017-08, Vol.88 (4), p.352-354
Main Authors: Wenzler, Eric, Deraedt, Matthew F, Harrington, Amanda T, Danizger, Larry H
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Avibactam
Azabicyclo Compounds - therapeutic use
Aztreonam
Aztreonam - therapeutic use
beta-Lactamase
beta-Lactamases - metabolism
Carbapenemase
Ceftazidime
Ceftazidime - therapeutic use
Drug Synergism
Enterobacteriaceae - drug effects
Enterobacteriaceae - metabolism
Etest
Gram-Negative Bacterial Infections - drug therapy
Gram-Negative Bacterial Infections - microbiology
Humans
Infectious Disease
Internal Medicine
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - metabolism
Serine - metabolism
Synergy
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Summary:Abstract This study assessed the in vitro synergy between ceftazidime, aztreonam, and ceftazidime-avibactam against serine and metallo-β-lactamase (MBL)-producing pathogens via the Etest MIC:MIC ratio and Agar-Etest synergy methods. The combination of aztreonam and ceftazidime-avibactam was synergistic against all Enterobacteriaceae . None of the tested combinations were consistently synergistic against IMP-producing P. aeruginosa.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2017.05.009