Fluconazole and its interaction with metal (II) complexes: SEM, Spectroscopic and antifungal studies

The human digestive tract contains some 100 trillion cells and thousands of species of micro-organisms may be present as normal flora of this tract as well as other mucocutaneous junctions of the body. Candida specie is the most common organism residing in these areas and can easily invade the inter...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2017-01, Vol.30 (1), p.187-194
Main Authors: Ali, Mohsin, Ahmed, Mansoor, Ahmed, Shakil, Ali, Syed Imran, Perveen, Samina, Mumtaz, Majid, Haider, Syed Moazzam, Nazim, Urooj
Format: Article
Language:English
Subjects:
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Aspergillus
Aspergillus niger - drug effects
Aspergillus niger - growth & development
Candida albicans
Candida albicans - drug effects
Candida albicans - growth & development
Chlorides - chemistry
Chlorides - pharmacology
Coordination compounds
Dosage and administration
Fluconazole
Fluconazole - analogs & derivatives
Fluconazole - chemistry
Fluconazole - pharmacology
Health aspects
Metals, Heavy - chemistry
Microbial Sensitivity Tests
Microscopy, Electron, Scanning
Proton Magnetic Resonance Spectroscopy
Spectrophotometry, Ultraviolet
Spectroscopy
Spectroscopy, Fourier Transform Infrared
Surface Properties
Technology, Pharmaceutical - methods
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Summary:The human digestive tract contains some 100 trillion cells and thousands of species of micro-organisms may be present as normal flora of this tract as well as other mucocutaneous junctions of the body. Candida specie is the most common organism residing in these areas and can easily invade the internal tissues in cases of loss of host defenses. Modifications of previously existing antifungal agents may provide new options to fight against these species. Inorganic compounds of different antifungals are under investigations. Present study report six complexes of fluconazole with Cu (II)), Fe(II), Cd(II), Co(II), Ni(II) and Mn(II) have been synthesized and characterized by elemental analysis, IR, UV and H-NMR. The elemental analysis and spectroscopic data were found in agreement with the expected values as the metal to ligand value was 1:2 ratios with two chlorides in coordination sphere. The morphology of each complex was studied using scanning electron microscope and compared with fluconazole molecule the flaky-slab rock like particles of pure fluconazole was also observed as reported earlier. However, the complexes of fluconazole were showed different morphology in their micrograph. Fluconazole and its complex derivatives have also been screened in vitro for their antifungal activity against Candida albican and Aspergillus niger by MIC method. The complexes showed varied activity ranging from 2-20%.
ISSN:1011-601X