Defining the role of liver biopsy in the assessment of liver fibrosis in patients with Fontan circulation—reply

To the Editor: We would like to thank Haugk and colleagues for their letter and the opportunity to address their questions as they move forward with developing a liver biopsy surveillance program for adults with failing Fontan circulation. The strength of the Sirius red stain is that its contrast le...

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Bibliographic Details
Published in:Human pathology 2017-11, Vol.69, p.141-141
Main Authors: Surrey, Lea F., MD, Russo, Pierre, MD, Rychik, Jack, MD, Goldberg, David J., MD, Dodds, Kathryn, CRNP, O'Byrne, Michael L., MDMSCE, Glatz, Andrew C., MDMSCE, Rand, Elizabeth B., MD, Lin, Henry C., MD
Format: Article
Language:English
Subjects:
Biopsy
Liver
Pathology
Patients
Pediatrics
Quantitative analysis
Stains & staining
Surveillance
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Summary:To the Editor: We would like to thank Haugk and colleagues for their letter and the opportunity to address their questions as they move forward with developing a liver biopsy surveillance program for adults with failing Fontan circulation. The strength of the Sirius red stain is that its contrast lends itself better to computer discrimination than the trichrome stain, although the trichrome stain (in our experience) allows better morphologic distinction of all the components in a liver biopsy. In our experience, there were a few patients receiving anticoagulation prior to and following the liver biopsy procedure in whom there were minor bleeding issues and one re-admission with more significant bleeding.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2017.04.029