Serine and Functional Metabolites in Cancer

Folate metabolism functions to supply one-carbon units that are vital for a range of biochemical reactions. Cancer cells can utilise serine as a major source of one-carbon units, rendering them dependent upon extracellular serine uptake or de novo serine synthesis for maximal growth and proliferatio...

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Bibliographic Details
Published in:Trends in cell biology 2017-09, Vol.27 (9), p.645-657
Main Authors: Newman, Alice C, Maddocks, Oliver D.K
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Animals
Biosynthesis
Cancer
Carbon
Carbon - metabolism
Cell Proliferation - physiology
Cell survival
Cells
Cellular manufacture
Chemical reactions
Folic acid
functional metabolites
Humans
Metabolism
Metabolites
Methionine
NAD
Neoplasms - metabolism
Nucleotides
one-carbon metabolism
Pathology
Serine
Serine - metabolism
Studies
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Summary:Folate metabolism functions to supply one-carbon units that are vital for a range of biochemical reactions. Cancer cells can utilise serine as a major source of one-carbon units, rendering them dependent upon extracellular serine uptake or de novo serine synthesis for maximal growth and proliferation. One-carbon units are required for the production of critical cellular components, such as nucleotides, which enable cancer cells to maintain high proliferate rates. Of recent interest, one-carbon metabolism contributes to the biosynthesis and recycling of functional metabolites, such as ATP, S -adenosyl-methionine (SAM), and NAD(P)H, with important downstream consequences for cancer cell survival. In this review, we describe recent advances in our understanding of the importance of one-carbon metabolism in cancer, focussing upon the routes through which cancer cells obtain and use one-carbon units.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2017.05.001