Lung cancer samples preserved in liquid medium: One step beyond cytology

Lung cancer is one of the most common cancer types in men and women worldwide with a high mortality rate. World Health Organization (WHO) classification has accepted biopsy as the primary sample for lung cancer diagnosis, pathological classification and molecular testing for management of patients,...

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Bibliographic Details
Published in:Diagnostic cytopathology 2017-10, Vol.45 (10), p.915-921
Main Authors: Mariano, Vânia Sammartino, Leal, Letícia Ferro, Pastrez, Paula Roberta Aguiar, Silva, Estela Maria, Reis, Rui Manuel, Longatto‐Filho, Adhemar
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - standards
bronchial cytology
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Small Cell - metabolism
Carcinoma, Small Cell - pathology
Cytology
Humans
liquid medium
Lung cancer
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
molecular biomarkers
Molecular Diagnostic Techniques - methods
Molecular Diagnostic Techniques - standards
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Summary:Lung cancer is one of the most common cancer types in men and women worldwide with a high mortality rate. World Health Organization (WHO) classification has accepted biopsy as the primary sample for lung cancer diagnosis, pathological classification and molecular testing for management of patients, yet, the use of alternative sampling procedures is highly encouraged. Bronchial cytological samples require a less invasive collection technique and may be suitable for pathological and molecular analysis and storage in liquid medium. Furthermore, the molecular analysis of bronchial cytological samples allows the detection of molecular biomarkers, which may be useful for the selection of molecular targeted therapies. Thus, the purpose of this review is to describe the usefulness of bronchial cytological samples preserved in liquid medium from lung cancer patients for pathological diagnosis and molecular investigation.
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.23743