MicroRNAs and Fracture Healing

MicroRNAs (miRNAs) are small molecules found to have major regulatory roles in many biological processes. This review aims to provide an overview of the recent advances in knowledge of the role of miRNAs in fracture healing and bone repair. A search of the published literature was performed (using t...

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Bibliographic Details
Published in:Calcified tissue international 2017-10, Vol.101 (4), p.355-361
Main Author: Nugent, Mary
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Bone growth
Bone healing
Bones
Cell Biology
Endocrinology
Fractures
Growth factors
Life Sciences
MicroRNAs
miRNA
Molecular biology
Orthopedics
Osteoblasts
Osteoporosis
Review
Reviews
Therapeutic applications
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Summary:MicroRNAs (miRNAs) are small molecules found to have major regulatory roles in many biological processes. This review aims to provide an overview of the recent advances in knowledge of the role of miRNAs in fracture healing and bone repair. A search of the published literature was performed (using the PubMed database) to include all relevant studies published in English. These studies were then reviewed and the results condensed into this review paper. MiRNAs have now been shown to have significant alterations in expression levels in bone tissue in the presence of fractures. This is thought to be related to the process of fracture healing through effects on osteoblasts and bone growth factors. These small molecules are also detectable in the circulation where their expression appears to be altered by the presence of fractures. Although further research is required in this area, miRNAs may present an opportunity for future clinical applications in fracture management.
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-017-0296-x