Commentary on ‘dietary magnesium intake and fracture risk: data from a large prospective study’

Research studies on this topic have previously mainly focused on Ca and vitamin D intakes, but there has been a growing interest in the role of other nutrients including dietary Mg, for which there is a mechanistic rationale for epidemiological investigation. Bone represents the major body store of...

Full description

Saved in:
Bibliographic Details
Published in:British journal of nutrition 2017-05, Vol.117 (10), p.1454-1455
Main Author: Hayhoe, Richard P. G.
Format: Article
Language:English
Subjects:
Animal models
Arthritis
Biocompatibility
Biomedical materials
Bone density
Bone growth
Bone resorption
Bone turnover
Diet
Dietary intake
Dietary Surveys and Nutritional Epidemiology
Epidemiology
Food
Fractures
Fractures, Bone
Gender differences
Health risk assessment
Humans
Hydroxyapatite
Inflammation
Invited Commentary
Magnesium
Mechanical properties
Mens health
Metabolism
Nutrient deficiency
Nutrients
Nutrition research
Nutritional Status
Osteoclasts
Osteoporosis
Oxidative stress
Parathyroid
Parathyroid hormone
Population
Potassium
Prospective Studies
Public health
Risk
Stiffness
Surgical implants
Ultrasound
Vitamin D
Women
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Research studies on this topic have previously mainly focused on Ca and vitamin D intakes, but there has been a growing interest in the role of other nutrients including dietary Mg, for which there is a mechanistic rationale for epidemiological investigation. Bone represents the major body store of Mg, and experimental studies have shown Mg to be involved in bone metabolism, including having nitric-oxide dependent effects on osteoblast activity and osteoclast number, and affecting hydroxyapatite crystal formation and consequent bone stiffness(1). Ca homoeostasis, highly relevant to bone health, is modulated by Mg through parathyroid hormone and vitamin D, and Mg deficiency in animal models promotes pro-inflammatory cytokine secretion and oxidative stress which both stimulate osteoclastic bone resorption(1). (2)thus provides a useful addition to the literature supporting the relevance of dietary intake of Mg to osteoporotic fracture risk and, once reinforced by clinical trial data, raises the prospect of exploiting this relationship in nutritional public health strategies to improve bone health at a population level. (2015 ) Dietary magnesium and potassium intakes and circulating magnesium are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the EPIC-Norfolk cohort study . Farsinejad-Marj M , Saneei P & Esmaillzadeh A (2016...
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114517001337