Platelet inhibition after loading dose of prasugrel in patients with ST-elevation and non-ST-elevation acute coronary syndrome

The PRASFIT-ACS study showed the antiplatelet effect 2–4 h after prasugrel loading. However, there is little information about the antiplatelet effect 208 PRU as a cutoff value, STEMI patients had a higher prevalence of high on-treatment platelet reactivity at 2–6 h and 1 week after loading. Rapid a...

Full description

Saved in:
Bibliographic Details
Published in:Cardiovascular intervention and therapeutics 2018-07, Vol.33 (3), p.239-246
Main Authors: Wakabayashi, Shinichi, Kitahara, Hideki, Nishi, Takeshi, Sugimoto, Kazumasa, Nakayama, Takashi, Fujimoto, Yoshihide, Ariyoshi, Noritaka, Kobayashi, Yoshio
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - drug therapy
Aged
Blood Platelets - drug effects
Cardiology
Clopidogrel - adverse effects
Clopidogrel - therapeutic use
Female
Humans
Interventional Radiology
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Percutaneous Coronary Intervention - adverse effects
Platelet Aggregation Inhibitors - administration & dosage
Platelet Aggregation Inhibitors - adverse effects
Prasugrel Hydrochloride - administration & dosage
Prasugrel Hydrochloride - adverse effects
Prospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The PRASFIT-ACS study showed the antiplatelet effect 2–4 h after prasugrel loading. However, there is little information about the antiplatelet effect 208 PRU as a cutoff value, STEMI patients had a higher prevalence of high on-treatment platelet reactivity at 2–6 h and 1 week after loading. Rapid antiplatelet effect is not achieved by low-dose prasugrel loading in STEMI patients. Platelet inhibition occurs earlier in NSTE-ACS patients, although it takes ≥2 h after loading in the majority of patients.
ISSN:1868-4300
1868-4297
DOI:10.1007/s12928-017-0475-8