Angiogenesis biomarkers and their targeting ligands as potential targets for tumor angiogenesis

• Published in: Journal of cellular physiology 2018-04, Vol.233 (4), p.2949-2965
• Main Authors: Mashreghi, Mohammad, Azarpara, Hassan, Bazaz, Mahere R., Jafari, Arash, Masoudifar, Aria, Mirzaei, Hamed, Jaafari, Mahmoud R.
• Format: Article
• Language: English
• Subjects: Angiogenesis; Animals; Aptamers; Biomarkers; Biomarkers, Tumor - metabolism; Blood vessels; Cancer; Cancer therapies; Chemical compounds; Endothelial cells; Humans; Ligands; Microenvironments; MicroRNAs; miRNA; Neoplasm Proteins - metabolism; Neoplasms - blood supply; Neovascularization, Pathologic - metabolism; Nutrients; Oxygen; Peptides; Pharmacology; Proteins; Signal Transduction; target; Therapy; Tumor cells; Tumors
• ISSN: 0021-9541; 1097-4652
• DOI: 10.1002/jcp.26049

Angiogenesis is known as one of the hallmarks in cancer which could play a key role in providing oxygen and nutrients for tumor cells. It has been shown that tumor cannot grow without sufficient development of new blood vessels. Accordingly, targeting angiogenesis, especially endothelial cells, could be considered as a common therapeutic target in tumors and more investigation on already existing biomarkers and potentially new biomarkers of endothelial cells seems to be necessary in cancer therapy. Moreover, the use of effective targeting approaches such as proteins and peptides, aptamers, and small molecules is an important step for targeting biomarkers associated with endothelial cells and angiogenesis in cancer therapy. These agents are FDA approved, or are currently under investigation in pre‐clinical and clinical studies. Among various biomarkers for angiogenesis microRNAs are suitable candidates for target therapy. These molecules play key roles in tumor angiogenesis which exert their effect via targeting a variety of cellular and molecular pathways involved in tumor angiogenesis. Here, we summarize a variety of biomarkers which their expressions or their functions could change the function of endothelial cells in tumor microenvironments. Moreover, we highlighted various therapeutic agents which could target these biomarkers. Angiogenesis is known as one of the hallmarks in cancer which could play a key role in providing oxygen and nutrients for tumor cells. It has been shown that tumor cannot grow without sufficient development of new blood vessels. Accordingly, targeting angiogenesis, especially endothelial cells, could be considered as a common therapeutic target in tumors and more investigation on already existing biomarkers and potentially new biomarkers of endothelial cells seems to be necessary in cancer therapy. Moreover, the use of effective targeting approaches such as proteins and peptides, aptamers, and small molecules is an important step for targeting biomarkers associated with endothelial cells and angiogenesis in cancer therapy. These agents are FDA approved, or are currently under investigation in pre‐clinical and clinical studies. Among various biomarkers for angiogenesis microRNAs are suitable candidates for target therapy. These molecules play key roles in tumor angiogenesis which exert their effect via targeting a variety of cellular and molecular pathways involved in tumor angiogenesis. Here, we summarize a variety of biomarkers