Do packed red blood cell transfusions really worsen oncologic outcomes in colon cancer?

Background Data from small retrospective studies have argued that perioperative packed red blood cell transfusions may increase the risk of developing metastatic recurrence in cancer patients. This study tests this assumption in a large cohort spanning a decade of operatively treated colon cancer pa...

Full description

Saved in:
Bibliographic Details
Published in:Surgery 2017-09, Vol.162 (3), p.586-591
Main Authors: Amri, Ramzi, MD, PhD, Dinaux, Anne M., BSc, Leijssen, Lieve G.J., MD, Kunitake, Hiroko, MD, Bordeianou, Liliana G., MD, FACS, Berger, David L., MD, FACS
Format: Article
Language:English
Subjects:
Cohort Studies
Colectomy - methods
Colonic Neoplasms - mortality
Colonic Neoplasms - pathology
Colonic Neoplasms - therapy
Databases, Factual
Disease-Free Survival
Erythrocyte Transfusion - adverse effects
Erythrocyte Transfusion - methods
Female
Humans
Kaplan-Meier Estimate
Male
Neoplasm Invasiveness - pathology
Neoplasm Staging
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Reference Values
Retrospective Studies
Risk Assessment
Surgery
Survival Analysis
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Data from small retrospective studies have argued that perioperative packed red blood cell transfusions may increase the risk of developing metastatic recurrence in cancer patients. This study tests this assumption in a large cohort spanning a decade of operatively treated colon cancer patients. Methods All patients undergoing primary resection of a colon cancer at a tertiary care center between 2004–2014 ( n  = 1,423) were included in a retrospective review of a prospectively maintained data repository. Survival and disease-free survival were compared and also adjusted in multivariable Cox regression standardized for follow-up, American Society of Anesthesiologists score, age, sex, postoperative chemotherapy, baseline staging, and tumor grade. Results Of the 1,423 patients, 305 (21.4%) received a perioperative packed red blood cell transfusion during their index admission. During follow-up, overall mortality was greater in patients who received perioperative packed red blood cell (53.1% vs 30.9%; P  
ISSN:0039-6060
1532-7361
DOI:10.1016/j.surg.2017.03.024