Loading…
Do packed red blood cell transfusions really worsen oncologic outcomes in colon cancer?
Background Data from small retrospective studies have argued that perioperative packed red blood cell transfusions may increase the risk of developing metastatic recurrence in cancer patients. This study tests this assumption in a large cohort spanning a decade of operatively treated colon cancer pa...
Saved in:
| Published in: | Surgery 2017-09, Vol.162 (3), p.586-591 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c411t-663c576fdc953b5a0692fc5a4cd64f78eeb82c380f2c912a8a0311989b4e08103 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c411t-663c576fdc953b5a0692fc5a4cd64f78eeb82c380f2c912a8a0311989b4e08103 |
| container_end_page | 591 |
| container_issue | 3 |
| container_start_page | 586 |
| container_title | Surgery |
| container_volume | 162 |
| creator | Amri, Ramzi, MD, PhD Dinaux, Anne M., BSc Leijssen, Lieve G.J., MD Kunitake, Hiroko, MD Bordeianou, Liliana G., MD, FACS Berger, David L., MD, FACS |
| description | Background Data from small retrospective studies have argued that perioperative packed red blood cell transfusions may increase the risk of developing metastatic recurrence in cancer patients. This study tests this assumption in a large cohort spanning a decade of operatively treated colon cancer patients. Methods All patients undergoing primary resection of a colon cancer at a tertiary care center between 2004–2014 ( n = 1,423) were included in a retrospective review of a prospectively maintained data repository. Survival and disease-free survival were compared and also adjusted in multivariable Cox regression standardized for follow-up, American Society of Anesthesiologists score, age, sex, postoperative chemotherapy, baseline staging, and tumor grade. Results Of the 1,423 patients, 305 (21.4%) received a perioperative packed red blood cell transfusion during their index admission. During follow-up, overall mortality was greater in patients who received perioperative packed red blood cell (53.1% vs 30.9%; P |
| doi_str_mv | 10.1016/j.surg.2017.03.024 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1909239607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S003960601730243X</els_id><sourcerecordid>1909239607</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-663c576fdc953b5a0692fc5a4cd64f78eeb82c380f2c912a8a0311989b4e08103</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxS1ERbeFL8AB-cglYWwnTiwhUFXKH6lSDwXBzXKcSeWt117shGq_PY62cODAwWNp5r0n-zeEvGRQM2DyzbbOS7qrObCuBlEDb56QDWsFrzoh2VOyARCqkiDhlJzlvAUA1bD-GTnlfel2vN2Q7x8i3Rt7jyNN5Qw-xpFa9J7OyYQ8LdnFkMvMeH-gDzFlDDQGG328c5bGZbZxh5m6QNdeqSZYTO-fk5PJ-IwvHu9z8u3j1dfLz9X1zacvlxfXlW0YmysphW07OY1WtWJoDUjFJ9uaxo6ymboecei5FT1M3CrGTW9AMKZ6NTQIPQNxTl4fc_cp_lwwz3rn8vp-EzAuWTMFigsloStSfpTaFHNOOOl9cjuTDpqBXoHqrV6B6hWoBqEL0GJ69Zi_DDsc_1r-ECyCt0cBll_-cph0tg4Lg9EltLMeo_t__rt_7Na74Kzx93jAvI1LCoWfZjpzDfp2Xem6UdaJ1f5D_Ab2epwM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1909239607</pqid></control><display><type>article</type><title>Do packed red blood cell transfusions really worsen oncologic outcomes in colon cancer?</title><source>Elsevier</source><creator>Amri, Ramzi, MD, PhD ; Dinaux, Anne M., BSc ; Leijssen, Lieve G.J., MD ; Kunitake, Hiroko, MD ; Bordeianou, Liliana G., MD, FACS ; Berger, David L., MD, FACS</creator><creatorcontrib>Amri, Ramzi, MD, PhD ; Dinaux, Anne M., BSc ; Leijssen, Lieve G.J., MD ; Kunitake, Hiroko, MD ; Bordeianou, Liliana G., MD, FACS ; Berger, David L., MD, FACS</creatorcontrib><description>Background Data from small retrospective studies have argued that perioperative packed red blood cell transfusions may increase the risk of developing metastatic recurrence in cancer patients. This study tests this assumption in a large cohort spanning a decade of operatively treated colon cancer patients. Methods All patients undergoing primary resection of a colon cancer at a tertiary care center between 2004–2014 ( n = 1,423) were included in a retrospective review of a prospectively maintained data repository. Survival and disease-free survival were compared and also adjusted in multivariable Cox regression standardized for follow-up, American Society of Anesthesiologists score, age, sex, postoperative chemotherapy, baseline staging, and tumor grade. Results Of the 1,423 patients, 305 (21.4%) received a perioperative packed red blood cell transfusion during their index admission. During follow-up, overall mortality was greater in patients who received perioperative packed red blood cell (53.1% vs 30.9%; P < .001); however, there were no appreciable differences in rates of long-term distant recurrence (in patients without baseline metastasis 11.1% vs 13.9%; P = .25), or disease-specific mortality (21.3% vs 17.3%; P = .104; without baseline metastasis: 8.6% vs 8.9%; P = .89). Similarly, multivariable Cox regression showed no statistical difference in recurrence (hazard ratio: 0.83, 95% confidence interval, 0.83–1.26; P = .38) or disease-specific mortality (hazard ratio: 1.12, 95% confidence interval, 0.83–1.51; P = .47). Conclusion Mortality rates were significantly greater in patients with perioperative packed red blood cell transfusions, a finding that is backed by a body of evidence that associates perioperative packed red blood cell transfusion with comorbidity and serious illness, but contrary to earlier evidence, findings in our cohort do not support a hypothesis that perioperative perioperative packed red blood cell transfusions have a detrimental effect on recurrence rates of operatively treated colon cancer patients.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2017.03.024</identifier><identifier>PMID: 28606725</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cohort Studies ; Colectomy - methods ; Colonic Neoplasms - mortality ; Colonic Neoplasms - pathology ; Colonic Neoplasms - therapy ; Databases, Factual ; Disease-Free Survival ; Erythrocyte Transfusion - adverse effects ; Erythrocyte Transfusion - methods ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Reference Values ; Retrospective Studies ; Risk Assessment ; Surgery ; Survival Analysis ; Treatment Outcome</subject><ispartof>Surgery, 2017-09, Vol.162 (3), p.586-591</ispartof><rights>Elsevier Inc.</rights><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-663c576fdc953b5a0692fc5a4cd64f78eeb82c380f2c912a8a0311989b4e08103</citedby><cites>FETCH-LOGICAL-c411t-663c576fdc953b5a0692fc5a4cd64f78eeb82c380f2c912a8a0311989b4e08103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28606725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amri, Ramzi, MD, PhD</creatorcontrib><creatorcontrib>Dinaux, Anne M., BSc</creatorcontrib><creatorcontrib>Leijssen, Lieve G.J., MD</creatorcontrib><creatorcontrib>Kunitake, Hiroko, MD</creatorcontrib><creatorcontrib>Bordeianou, Liliana G., MD, FACS</creatorcontrib><creatorcontrib>Berger, David L., MD, FACS</creatorcontrib><title>Do packed red blood cell transfusions really worsen oncologic outcomes in colon cancer?</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Background Data from small retrospective studies have argued that perioperative packed red blood cell transfusions may increase the risk of developing metastatic recurrence in cancer patients. This study tests this assumption in a large cohort spanning a decade of operatively treated colon cancer patients. Methods All patients undergoing primary resection of a colon cancer at a tertiary care center between 2004–2014 ( n = 1,423) were included in a retrospective review of a prospectively maintained data repository. Survival and disease-free survival were compared and also adjusted in multivariable Cox regression standardized for follow-up, American Society of Anesthesiologists score, age, sex, postoperative chemotherapy, baseline staging, and tumor grade. Results Of the 1,423 patients, 305 (21.4%) received a perioperative packed red blood cell transfusion during their index admission. During follow-up, overall mortality was greater in patients who received perioperative packed red blood cell (53.1% vs 30.9%; P < .001); however, there were no appreciable differences in rates of long-term distant recurrence (in patients without baseline metastasis 11.1% vs 13.9%; P = .25), or disease-specific mortality (21.3% vs 17.3%; P = .104; without baseline metastasis: 8.6% vs 8.9%; P = .89). Similarly, multivariable Cox regression showed no statistical difference in recurrence (hazard ratio: 0.83, 95% confidence interval, 0.83–1.26; P = .38) or disease-specific mortality (hazard ratio: 1.12, 95% confidence interval, 0.83–1.51; P = .47). Conclusion Mortality rates were significantly greater in patients with perioperative packed red blood cell transfusions, a finding that is backed by a body of evidence that associates perioperative packed red blood cell transfusion with comorbidity and serious illness, but contrary to earlier evidence, findings in our cohort do not support a hypothesis that perioperative perioperative packed red blood cell transfusions have a detrimental effect on recurrence rates of operatively treated colon cancer patients.</description><subject>Cohort Studies</subject><subject>Colectomy - methods</subject><subject>Colonic Neoplasms - mortality</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colonic Neoplasms - therapy</subject><subject>Databases, Factual</subject><subject>Disease-Free Survival</subject><subject>Erythrocyte Transfusion - adverse effects</subject><subject>Erythrocyte Transfusion - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Reference Values</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kU9v1DAQxS1ERbeFL8AB-cglYWwnTiwhUFXKH6lSDwXBzXKcSeWt117shGq_PY62cODAwWNp5r0n-zeEvGRQM2DyzbbOS7qrObCuBlEDb56QDWsFrzoh2VOyARCqkiDhlJzlvAUA1bD-GTnlfel2vN2Q7x8i3Rt7jyNN5Qw-xpFa9J7OyYQ8LdnFkMvMeH-gDzFlDDQGG328c5bGZbZxh5m6QNdeqSZYTO-fk5PJ-IwvHu9z8u3j1dfLz9X1zacvlxfXlW0YmysphW07OY1WtWJoDUjFJ9uaxo6ymboecei5FT1M3CrGTW9AMKZ6NTQIPQNxTl4fc_cp_lwwz3rn8vp-EzAuWTMFigsloStSfpTaFHNOOOl9cjuTDpqBXoHqrV6B6hWoBqEL0GJ69Zi_DDsc_1r-ECyCt0cBll_-cph0tg4Lg9EltLMeo_t__rt_7Na74Kzx93jAvI1LCoWfZjpzDfp2Xem6UdaJ1f5D_Ab2epwM</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Amri, Ramzi, MD, PhD</creator><creator>Dinaux, Anne M., BSc</creator><creator>Leijssen, Lieve G.J., MD</creator><creator>Kunitake, Hiroko, MD</creator><creator>Bordeianou, Liliana G., MD, FACS</creator><creator>Berger, David L., MD, FACS</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Do packed red blood cell transfusions really worsen oncologic outcomes in colon cancer?</title><author>Amri, Ramzi, MD, PhD ; Dinaux, Anne M., BSc ; Leijssen, Lieve G.J., MD ; Kunitake, Hiroko, MD ; Bordeianou, Liliana G., MD, FACS ; Berger, David L., MD, FACS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-663c576fdc953b5a0692fc5a4cd64f78eeb82c380f2c912a8a0311989b4e08103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Cohort Studies</topic><topic>Colectomy - methods</topic><topic>Colonic Neoplasms - mortality</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colonic Neoplasms - therapy</topic><topic>Databases, Factual</topic><topic>Disease-Free Survival</topic><topic>Erythrocyte Transfusion - adverse effects</topic><topic>Erythrocyte Transfusion - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Reference Values</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Surgery</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amri, Ramzi, MD, PhD</creatorcontrib><creatorcontrib>Dinaux, Anne M., BSc</creatorcontrib><creatorcontrib>Leijssen, Lieve G.J., MD</creatorcontrib><creatorcontrib>Kunitake, Hiroko, MD</creatorcontrib><creatorcontrib>Bordeianou, Liliana G., MD, FACS</creatorcontrib><creatorcontrib>Berger, David L., MD, FACS</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amri, Ramzi, MD, PhD</au><au>Dinaux, Anne M., BSc</au><au>Leijssen, Lieve G.J., MD</au><au>Kunitake, Hiroko, MD</au><au>Bordeianou, Liliana G., MD, FACS</au><au>Berger, David L., MD, FACS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do packed red blood cell transfusions really worsen oncologic outcomes in colon cancer?</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>162</volume><issue>3</issue><spage>586</spage><epage>591</epage><pages>586-591</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><abstract>Background Data from small retrospective studies have argued that perioperative packed red blood cell transfusions may increase the risk of developing metastatic recurrence in cancer patients. This study tests this assumption in a large cohort spanning a decade of operatively treated colon cancer patients. Methods All patients undergoing primary resection of a colon cancer at a tertiary care center between 2004–2014 ( n = 1,423) were included in a retrospective review of a prospectively maintained data repository. Survival and disease-free survival were compared and also adjusted in multivariable Cox regression standardized for follow-up, American Society of Anesthesiologists score, age, sex, postoperative chemotherapy, baseline staging, and tumor grade. Results Of the 1,423 patients, 305 (21.4%) received a perioperative packed red blood cell transfusion during their index admission. During follow-up, overall mortality was greater in patients who received perioperative packed red blood cell (53.1% vs 30.9%; P < .001); however, there were no appreciable differences in rates of long-term distant recurrence (in patients without baseline metastasis 11.1% vs 13.9%; P = .25), or disease-specific mortality (21.3% vs 17.3%; P = .104; without baseline metastasis: 8.6% vs 8.9%; P = .89). Similarly, multivariable Cox regression showed no statistical difference in recurrence (hazard ratio: 0.83, 95% confidence interval, 0.83–1.26; P = .38) or disease-specific mortality (hazard ratio: 1.12, 95% confidence interval, 0.83–1.51; P = .47). Conclusion Mortality rates were significantly greater in patients with perioperative packed red blood cell transfusions, a finding that is backed by a body of evidence that associates perioperative packed red blood cell transfusion with comorbidity and serious illness, but contrary to earlier evidence, findings in our cohort do not support a hypothesis that perioperative perioperative packed red blood cell transfusions have a detrimental effect on recurrence rates of operatively treated colon cancer patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28606725</pmid><doi>10.1016/j.surg.2017.03.024</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-6060 |
| ispartof | Surgery, 2017-09, Vol.162 (3), p.586-591 |
| issn | 0039-6060 1532-7361 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1909239607 |
| source | Elsevier |
| subjects | Cohort Studies Colectomy - methods Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colonic Neoplasms - therapy Databases, Factual Disease-Free Survival Erythrocyte Transfusion - adverse effects Erythrocyte Transfusion - methods Female Humans Kaplan-Meier Estimate Male Neoplasm Invasiveness - pathology Neoplasm Staging Predictive Value of Tests Prognosis Proportional Hazards Models Reference Values Retrospective Studies Risk Assessment Surgery Survival Analysis Treatment Outcome |
| title | Do packed red blood cell transfusions really worsen oncologic outcomes in colon cancer? |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T20%3A02%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Do%20packed%20red%20blood%20cell%20transfusions%20really%20worsen%20oncologic%20outcomes%20in%20colon%20cancer?&rft.jtitle=Surgery&rft.au=Amri,%20Ramzi,%20MD,%20PhD&rft.date=2017-09-01&rft.volume=162&rft.issue=3&rft.spage=586&rft.epage=591&rft.pages=586-591&rft.issn=0039-6060&rft.eissn=1532-7361&rft_id=info:doi/10.1016/j.surg.2017.03.024&rft_dat=%3Cproquest_cross%3E1909239607%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c411t-663c576fdc953b5a0692fc5a4cd64f78eeb82c380f2c912a8a0311989b4e08103%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1909239607&rft_id=info:pmid/28606725&rfr_iscdi=true |