Ventricular-arterial coupling in centenarians without cardiovascular diseases

Background Ventricular-arterial (VA) coupling is a central determinant of cardiovascular system performance and cardiac energetics. This index is expressed by the Ea/Ees ratio, where the effective arterial elastance (Ea) indicates the net arterial load exerted on the left ventricle and the left vent...

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Bibliographic Details
Published in:Aging clinical and experimental research 2018-04, Vol.30 (4), p.367-373
Main Authors: Sonaglioni, Andrea, Baravelli, Massimo, Lombardo, Michele, Sommese, Carmen, Anzà, Claudio, Kirk, Jonathan A., Padeletti, Luigi
Format: Article
Language:English
Subjects:
Aged, 80 and over
Aging
Arteries - physiology
Blood Pressure
Cardiology
Cardiovascular disease
Diabetes
Echocardiography
Female
Geriatrics/Gerontology
Heart failure
Humans
Hypertension
Male
Medicine
Medicine & Public Health
Oldest old people
Original Article
Pulmonary arteries
Sex Characteristics
Stroke
Values
Velocity
Ventricular Function, Left - physiology
Womens health
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Summary:Background Ventricular-arterial (VA) coupling is a central determinant of cardiovascular system performance and cardiac energetics. This index is expressed by the Ea/Ees ratio, where the effective arterial elastance (Ea) indicates the net arterial load exerted on the left ventricle and the left ventricular end-systolic elastance (Ees) is a load-independent measure of left ventricular chamber performance. Methods Thirty-three centenarians (100.6 ± 1.2 years, range 99–105 years, 10 M) without cardiovascular diseases underwent a complete echocardiographic evaluation and an instantaneous arterial blood pressure measurement, to characterize the Ea/Ees ratio and its two determinants indexed to body surface area. Results VA coupling was markedly reduced (Ea/Ees ratio 0.40 ± 0.1), reflecting a disproportionate increase in Ees index (8.5 ± 2.2 mmHg/ml/m 2 ) compared with Ea index (3.2 ± 0.8 mmHg/ml/m 2 ). Notably, the coupling ratio was significantly lower in women (0.37 ± 0.1) than in men (0.45 ± 0.1, p  = 0.0003), due to an increase in Ees index significantly greater in women (9.4 ± 1.9 mmHg/ml/m 2 ) than in men (6.5 ± 1.5 mmHg/ml/m 2 , p  = 0.0002). Using multivariate regression analysis, only female gender ( β coefficient −0.04, p  = 0.01) and relative wall thickness ( β coefficient −0.49, p  
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-017-0783-y