Loading…
Ventricular-arterial coupling in centenarians without cardiovascular diseases
Background Ventricular-arterial (VA) coupling is a central determinant of cardiovascular system performance and cardiac energetics. This index is expressed by the Ea/Ees ratio, where the effective arterial elastance (Ea) indicates the net arterial load exerted on the left ventricle and the left vent...
Saved in:
| Published in: | Aging clinical and experimental research 2018-04, Vol.30 (4), p.367-373 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c372t-4db8a073995e7ae6d2484f433cf6ad973fa0352d37bcd7ecc3dc191b366196b63 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c372t-4db8a073995e7ae6d2484f433cf6ad973fa0352d37bcd7ecc3dc191b366196b63 |
| container_end_page | 373 |
| container_issue | 4 |
| container_start_page | 367 |
| container_title | Aging clinical and experimental research |
| container_volume | 30 |
| creator | Sonaglioni, Andrea Baravelli, Massimo Lombardo, Michele Sommese, Carmen Anzà, Claudio Kirk, Jonathan A. Padeletti, Luigi |
| description | Background
Ventricular-arterial (VA) coupling is a central determinant of cardiovascular system performance and cardiac energetics. This index is expressed by the Ea/Ees ratio, where the effective arterial elastance (Ea) indicates the net arterial load exerted on the left ventricle and the left ventricular end-systolic elastance (Ees) is a load-independent measure of left ventricular chamber performance.
Methods
Thirty-three centenarians (100.6 ± 1.2 years, range 99–105 years, 10 M) without cardiovascular diseases underwent a complete echocardiographic evaluation and an instantaneous arterial blood pressure measurement, to characterize the Ea/Ees ratio and its two determinants indexed to body surface area.
Results
VA coupling was markedly reduced (Ea/Ees ratio 0.40 ± 0.1), reflecting a disproportionate increase in Ees index (8.5 ± 2.2 mmHg/ml/m
2
) compared with Ea index (3.2 ± 0.8 mmHg/ml/m
2
). Notably, the coupling ratio was significantly lower in women (0.37 ± 0.1) than in men (0.45 ± 0.1,
p
= 0.0003), due to an increase in Ees index significantly greater in women (9.4 ± 1.9 mmHg/ml/m
2
) than in men (6.5 ± 1.5 mmHg/ml/m
2
,
p
= 0.0002). Using multivariate regression analysis, only female gender (
β
coefficient −0.04,
p
= 0.01) and relative wall thickness (
β
coefficient −0.49,
p
|
| doi_str_mv | 10.1007/s40520-017-0783-y |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1910339431</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1910339431</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-4db8a073995e7ae6d2484f433cf6ad973fa0352d37bcd7ecc3dc191b366196b63</originalsourceid><addsrcrecordid>eNp1kM1PwyAchonRuDn9A7yYJl68VKE_Cu3RLH4lM17UK6FAJ0tHJ7Sa_fcyOz9i4gn48bwv5EHomOBzgjG_CBTnGU4x4SnmBaTrHTQmPE4KIOXur_0IHYSwwJiSeNhHo6xghBU5HaP7Z-M6b1XfSJ9K3xlvZZOotl811s0T6xIVAeNknLuQvNvupe27REmvbfsmw2cw0TYYGUw4RHu1bII52q4T9HR99Ti9TWcPN3fTy1mqgGddSnVVSMyhLHPDpWE6owWtKYCqmdQlh1piyDMNvFKaG6VAK1KSChgjJasYTNDZ0Lvy7WtvQieWNijTNNKZtg8iwhigpEAievoHXbS9d_F3IgNaEsIxzyNFBkr5NgRvarHydin9WhAsNq7F4FpE12LjWqxj5mTb3FdLo78TX3IjkA1AiFdubvzP0_-3fgBdMIrS</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2349117075</pqid></control><display><type>article</type><title>Ventricular-arterial coupling in centenarians without cardiovascular diseases</title><source>Springer Nature</source><creator>Sonaglioni, Andrea ; Baravelli, Massimo ; Lombardo, Michele ; Sommese, Carmen ; Anzà, Claudio ; Kirk, Jonathan A. ; Padeletti, Luigi</creator><creatorcontrib>Sonaglioni, Andrea ; Baravelli, Massimo ; Lombardo, Michele ; Sommese, Carmen ; Anzà, Claudio ; Kirk, Jonathan A. ; Padeletti, Luigi</creatorcontrib><description>Background
Ventricular-arterial (VA) coupling is a central determinant of cardiovascular system performance and cardiac energetics. This index is expressed by the Ea/Ees ratio, where the effective arterial elastance (Ea) indicates the net arterial load exerted on the left ventricle and the left ventricular end-systolic elastance (Ees) is a load-independent measure of left ventricular chamber performance.
Methods
Thirty-three centenarians (100.6 ± 1.2 years, range 99–105 years, 10 M) without cardiovascular diseases underwent a complete echocardiographic evaluation and an instantaneous arterial blood pressure measurement, to characterize the Ea/Ees ratio and its two determinants indexed to body surface area.
Results
VA coupling was markedly reduced (Ea/Ees ratio 0.40 ± 0.1), reflecting a disproportionate increase in Ees index (8.5 ± 2.2 mmHg/ml/m
2
) compared with Ea index (3.2 ± 0.8 mmHg/ml/m
2
). Notably, the coupling ratio was significantly lower in women (0.37 ± 0.1) than in men (0.45 ± 0.1,
p
= 0.0003), due to an increase in Ees index significantly greater in women (9.4 ± 1.9 mmHg/ml/m
2
) than in men (6.5 ± 1.5 mmHg/ml/m
2
,
p
= 0.0002). Using multivariate regression analysis, only female gender (
β
coefficient −0.04,
p
= 0.01) and relative wall thickness (
β
coefficient −0.49,
p
< 0.0001) showed a significant inverse correlation to VA coupling.
Conclusions
Our analysis in a population of centenarians without overt cardiovascular disease revealed very low values of VA coupling, especially in women. Both a LV structural remodeling as well as a high aortic elastance might have contributed to a secondary disproportionate increase in myocardial stiffness.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-017-0783-y</identifier><identifier>PMID: 28616854</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged, 80 and over ; Aging ; Arteries - physiology ; Blood Pressure ; Cardiology ; Cardiovascular disease ; Diabetes ; Echocardiography ; Female ; Geriatrics/Gerontology ; Heart failure ; Humans ; Hypertension ; Male ; Medicine ; Medicine & Public Health ; Oldest old people ; Original Article ; Pulmonary arteries ; Sex Characteristics ; Stroke ; Values ; Velocity ; Ventricular Function, Left - physiology ; Womens health</subject><ispartof>Aging clinical and experimental research, 2018-04, Vol.30 (4), p.367-373</ispartof><rights>Springer International Publishing AG 2017</rights><rights>Aging Clinical and Experimental Research is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-4db8a073995e7ae6d2484f433cf6ad973fa0352d37bcd7ecc3dc191b366196b63</citedby><cites>FETCH-LOGICAL-c372t-4db8a073995e7ae6d2484f433cf6ad973fa0352d37bcd7ecc3dc191b366196b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28616854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sonaglioni, Andrea</creatorcontrib><creatorcontrib>Baravelli, Massimo</creatorcontrib><creatorcontrib>Lombardo, Michele</creatorcontrib><creatorcontrib>Sommese, Carmen</creatorcontrib><creatorcontrib>Anzà, Claudio</creatorcontrib><creatorcontrib>Kirk, Jonathan A.</creatorcontrib><creatorcontrib>Padeletti, Luigi</creatorcontrib><title>Ventricular-arterial coupling in centenarians without cardiovascular diseases</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background
Ventricular-arterial (VA) coupling is a central determinant of cardiovascular system performance and cardiac energetics. This index is expressed by the Ea/Ees ratio, where the effective arterial elastance (Ea) indicates the net arterial load exerted on the left ventricle and the left ventricular end-systolic elastance (Ees) is a load-independent measure of left ventricular chamber performance.
Methods
Thirty-three centenarians (100.6 ± 1.2 years, range 99–105 years, 10 M) without cardiovascular diseases underwent a complete echocardiographic evaluation and an instantaneous arterial blood pressure measurement, to characterize the Ea/Ees ratio and its two determinants indexed to body surface area.
Results
VA coupling was markedly reduced (Ea/Ees ratio 0.40 ± 0.1), reflecting a disproportionate increase in Ees index (8.5 ± 2.2 mmHg/ml/m
2
) compared with Ea index (3.2 ± 0.8 mmHg/ml/m
2
). Notably, the coupling ratio was significantly lower in women (0.37 ± 0.1) than in men (0.45 ± 0.1,
p
= 0.0003), due to an increase in Ees index significantly greater in women (9.4 ± 1.9 mmHg/ml/m
2
) than in men (6.5 ± 1.5 mmHg/ml/m
2
,
p
= 0.0002). Using multivariate regression analysis, only female gender (
β
coefficient −0.04,
p
= 0.01) and relative wall thickness (
β
coefficient −0.49,
p
< 0.0001) showed a significant inverse correlation to VA coupling.
Conclusions
Our analysis in a population of centenarians without overt cardiovascular disease revealed very low values of VA coupling, especially in women. Both a LV structural remodeling as well as a high aortic elastance might have contributed to a secondary disproportionate increase in myocardial stiffness.</description><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Arteries - physiology</subject><subject>Blood Pressure</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Diabetes</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Geriatrics/Gerontology</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oldest old people</subject><subject>Original Article</subject><subject>Pulmonary arteries</subject><subject>Sex Characteristics</subject><subject>Stroke</subject><subject>Values</subject><subject>Velocity</subject><subject>Ventricular Function, Left - physiology</subject><subject>Womens health</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kM1PwyAchonRuDn9A7yYJl68VKE_Cu3RLH4lM17UK6FAJ0tHJ7Sa_fcyOz9i4gn48bwv5EHomOBzgjG_CBTnGU4x4SnmBaTrHTQmPE4KIOXur_0IHYSwwJiSeNhHo6xghBU5HaP7Z-M6b1XfSJ9K3xlvZZOotl811s0T6xIVAeNknLuQvNvupe27REmvbfsmw2cw0TYYGUw4RHu1bII52q4T9HR99Ti9TWcPN3fTy1mqgGddSnVVSMyhLHPDpWE6owWtKYCqmdQlh1piyDMNvFKaG6VAK1KSChgjJasYTNDZ0Lvy7WtvQieWNijTNNKZtg8iwhigpEAievoHXbS9d_F3IgNaEsIxzyNFBkr5NgRvarHydin9WhAsNq7F4FpE12LjWqxj5mTb3FdLo78TX3IjkA1AiFdubvzP0_-3fgBdMIrS</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Sonaglioni, Andrea</creator><creator>Baravelli, Massimo</creator><creator>Lombardo, Michele</creator><creator>Sommese, Carmen</creator><creator>Anzà, Claudio</creator><creator>Kirk, Jonathan A.</creator><creator>Padeletti, Luigi</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180401</creationdate><title>Ventricular-arterial coupling in centenarians without cardiovascular diseases</title><author>Sonaglioni, Andrea ; Baravelli, Massimo ; Lombardo, Michele ; Sommese, Carmen ; Anzà, Claudio ; Kirk, Jonathan A. ; Padeletti, Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-4db8a073995e7ae6d2484f433cf6ad973fa0352d37bcd7ecc3dc191b366196b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Arteries - physiology</topic><topic>Blood Pressure</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Diabetes</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Geriatrics/Gerontology</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oldest old people</topic><topic>Original Article</topic><topic>Pulmonary arteries</topic><topic>Sex Characteristics</topic><topic>Stroke</topic><topic>Values</topic><topic>Velocity</topic><topic>Ventricular Function, Left - physiology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sonaglioni, Andrea</creatorcontrib><creatorcontrib>Baravelli, Massimo</creatorcontrib><creatorcontrib>Lombardo, Michele</creatorcontrib><creatorcontrib>Sommese, Carmen</creatorcontrib><creatorcontrib>Anzà, Claudio</creatorcontrib><creatorcontrib>Kirk, Jonathan A.</creatorcontrib><creatorcontrib>Padeletti, Luigi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sonaglioni, Andrea</au><au>Baravelli, Massimo</au><au>Lombardo, Michele</au><au>Sommese, Carmen</au><au>Anzà, Claudio</au><au>Kirk, Jonathan A.</au><au>Padeletti, Luigi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ventricular-arterial coupling in centenarians without cardiovascular diseases</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>30</volume><issue>4</issue><spage>367</spage><epage>373</epage><pages>367-373</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background
Ventricular-arterial (VA) coupling is a central determinant of cardiovascular system performance and cardiac energetics. This index is expressed by the Ea/Ees ratio, where the effective arterial elastance (Ea) indicates the net arterial load exerted on the left ventricle and the left ventricular end-systolic elastance (Ees) is a load-independent measure of left ventricular chamber performance.
Methods
Thirty-three centenarians (100.6 ± 1.2 years, range 99–105 years, 10 M) without cardiovascular diseases underwent a complete echocardiographic evaluation and an instantaneous arterial blood pressure measurement, to characterize the Ea/Ees ratio and its two determinants indexed to body surface area.
Results
VA coupling was markedly reduced (Ea/Ees ratio 0.40 ± 0.1), reflecting a disproportionate increase in Ees index (8.5 ± 2.2 mmHg/ml/m
2
) compared with Ea index (3.2 ± 0.8 mmHg/ml/m
2
). Notably, the coupling ratio was significantly lower in women (0.37 ± 0.1) than in men (0.45 ± 0.1,
p
= 0.0003), due to an increase in Ees index significantly greater in women (9.4 ± 1.9 mmHg/ml/m
2
) than in men (6.5 ± 1.5 mmHg/ml/m
2
,
p
= 0.0002). Using multivariate regression analysis, only female gender (
β
coefficient −0.04,
p
= 0.01) and relative wall thickness (
β
coefficient −0.49,
p
< 0.0001) showed a significant inverse correlation to VA coupling.
Conclusions
Our analysis in a population of centenarians without overt cardiovascular disease revealed very low values of VA coupling, especially in women. Both a LV structural remodeling as well as a high aortic elastance might have contributed to a secondary disproportionate increase in myocardial stiffness.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>28616854</pmid><doi>10.1007/s40520-017-0783-y</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1720-8319 |
| ispartof | Aging clinical and experimental research, 2018-04, Vol.30 (4), p.367-373 |
| issn | 1720-8319 1594-0667 1720-8319 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1910339431 |
| source | Springer Nature |
| subjects | Aged, 80 and over Aging Arteries - physiology Blood Pressure Cardiology Cardiovascular disease Diabetes Echocardiography Female Geriatrics/Gerontology Heart failure Humans Hypertension Male Medicine Medicine & Public Health Oldest old people Original Article Pulmonary arteries Sex Characteristics Stroke Values Velocity Ventricular Function, Left - physiology Womens health |
| title | Ventricular-arterial coupling in centenarians without cardiovascular diseases |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T21%3A49%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ventricular-arterial%20coupling%20in%20centenarians%20without%20cardiovascular%20diseases&rft.jtitle=Aging%20clinical%20and%20experimental%20research&rft.au=Sonaglioni,%20Andrea&rft.date=2018-04-01&rft.volume=30&rft.issue=4&rft.spage=367&rft.epage=373&rft.pages=367-373&rft.issn=1720-8319&rft.eissn=1720-8319&rft_id=info:doi/10.1007/s40520-017-0783-y&rft_dat=%3Cproquest_cross%3E1910339431%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c372t-4db8a073995e7ae6d2484f433cf6ad973fa0352d37bcd7ecc3dc191b366196b63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2349117075&rft_id=info:pmid/28616854&rfr_iscdi=true |