Effect of aerobic interval training on serum IL-10, TNFα, and adipokines levels in women with multiple sclerosis: possible relations with fatigue and quality of life

• Published in: Endocrine 2017-08, Vol.57 (2), p.262-271
• Main Authors: Mokhtarzade, Motahare, Ranjbar, Rouholah, Majdinasab, Nastaran, Patel, Darpan, Molanouri Shamsi, Mehdieh
• Format: Article
• Language: English
• Subjects: Adipokines - blood; Adiponectin; Adipose tissue; Adult; Aerobics; Anaerobic Threshold; Anthropometry; Cytokines; Diabetes; Endocrinology; Exercise; Exercise - physiology; Exercise Therapy - methods; Fatigue; Fatigue - prevention & control; Female; Fitness training programs; Humanities and Social Sciences; Humans; Immune system; Inflammation; Interleukin 10; Interleukin-10 - blood; Internal Medicine; Leptin; Leptin - blood; Medicine; Medicine & Public Health; multidisciplinary; Multiple sclerosis; Multiple Sclerosis - blood; Multiple Sclerosis - psychology; Multiple Sclerosis - therapy; Original Article; Oxygen Consumption; Physical fitness; Quality of Life; Science; Studies; Tumor Necrosis Factor-alpha - blood
• ISSN: 1355-008X; 1559-0100
• DOI: 10.1007/s12020-017-1337-y

Purpose Multiple sclerosis is associated with immune system dysfunction and chronic inflammation; however, possible relations between immunologic and metabolic factors and some psychological indexes such as fatigue and quality of life, especially in relation to exercise training, have not yet been investigated. The present study was designed to investigate the effect of aerobic interval training on interleukin-10/tumor necrosis factor ratio and adipokine (leptin and adiponectin) concentrations in women with multiple sclerosis. Furthermore, the relationship between these factors with fatigue and quality of life were assessed. Methods Forty women with multiple sclerosis (Expanded Disability Status Scale ≤3) were randomized into either a non-exercising control or training group. The training group performed 8-weeks of upper and lower limb aerobic interval training. Serum concentrations of tumor necrosis factorα, interleukin-10, leptin, and adiponectin were measured before and after the 8-week intervention. Moreover, antropometric measures and measures for fatigue and quality of life were determined at the onset of and after exercise training. Results The results revealed that leptin and tumor necrosis factor α levels significantly decreased subsequent to the aerobic interval training. Although blood adiponectin levels considerably increased in the training group, interleukin-10 and interleukin-10/tumor necrosis factorα ratio underwent no substantial change after the exercise training. In addition, the aerobic interval training was associated with improvement in fatigue, quality of life, and maximal oxygen consumption. Conclusions Our findings suggested that aerobic interval training can be an effective strategy for managing the immune system at least by its significant impact on inflammatory cytokines and adipokines levels in women with multiple sclerosis. Additionally, this positive impact improved fatigue and adipose tissue indicators.