Prediction of the estimated 5-year risk of sudden cardiac death and syncope or non-sustained ventricular tachycardia in patients with hypertrophic cardiomyopathy using late gadolinium enhancement and extracellular volume CMR

• Published in: European radiology 2017-12, Vol.27 (12), p.5136-5145
• Main Authors: Avanesov, Maxim, Münch, Julia, Weinrich, Julius, Well, Lennart, Säring, Dennis, Stehning, Christian, Tahir, Enver, Bohnen, Sebastian, Radunski, Ulf K., Muellerleile, Kai, Adam, Gerhard, Patten, Monica, Lund, Gunnar
• Format: Article
• Language: English
• Subjects: Adult; Aged; Area Under Curve; Cardiac; Cardiac arrhythmia; Cardiac Volume; Cardiomyopathy; Cardiomyopathy, Hypertrophic - diagnostic imaging; Case-Control Studies; Contrast Media; Death, Sudden, Cardiac - pathology; Defibrillators; Diagnostic Radiology; Diagnostic systems; Female; Gadolinium; Heart; Heart diseases; Humans; Imaging; Implantation; Internal Medicine; Interventional Radiology; Magnetic resonance; Magnetic Resonance Imaging - methods; Male; Medical prognosis; Medicine; Medicine & Public Health; Middle Aged; Myocardium - pathology; Neuroradiology; Patients; Probability; Radiology; Risk; Risk Assessment - methods; Syncope; Syncope - pathology; Tachycardia; Tachycardia, Ventricular; Ultrasound; Ventricle
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-017-4869-x

Objectives To evaluate the ability of late gadolinium enhancement (LGE) and mapping cardiac magnetic resonance (CMR) including native T1 and global extracellular volume (ECV) to identify hypertrophic cardiomyopathy (HCM) patients at risk for sudden cardiac death (SCD) and to predict syncope or non-sustained ventricular tachycardia (VT). Methods A 1.5-T CMR was performed in 73 HCM patients and 16 controls. LGE size was quantified using the 3SD, 5SD and full width at half maximum (FWHM) method. T1 and ECV maps were generated by a 3(3)5 modified Look-Locker inversion recovery sequence. Receiver-operating curve analysis evaluated the best parameter to identify patients with increased SCD risk ≥4% and patients with syncope or non-sustained VT. Results Global ECV was the best predictor of SCD risk with an area under the curve (AUC) of 0.83. LGE size was significantly inferior to global ECV with an AUC of 0.68, 0.70 and 0.70 (all P < 0.05) for 3SD-, 5SD- and FWHM-LGE, respectively. Combined use of the SCD risk score and global ECV significantly improved the diagnostic accuracy to identify HCM patients with syncope or non-sustained VT. Conclusions Combined use of the SCD risk score and global ECV has the potential to improve HCM patient selection, benefiting most implantable cardioverter defibrillators. Key Points • Global ECV identified the best HCM patients with increased SCD risk. • Global ECV performed equally well compared to a SCD risk score. • Combined use of the SCD risk score and global ECV improved test accuracy. • Combined use potentially improves selection of HCM patients for ICD implantation.