Dual Role of H2O2 in Palladium-Catalyzed Dioxygenation of Terminal Alkenes

A palladium-catalyzed, environmentally friendly dioxygenation reaction of simple alkenes has been developed that enabled rapid assembly of valuable α-hydroxy ketones with high atom economy. Notably, control experiments and 18O isotope-labeling experiments established that H2O2 played a dominant dual...

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Bibliographic Details
Published in:Organic letters 2017-07, Vol.19 (13), p.3354-3357
Main Authors: Huang, Jiuzhong, Li, Jianxiao, Zheng, Jia, Wu, Wanqing, Hu, Weigao, Ouyang, Lu, Jiang, Huanfeng
Format: Article
Language:English
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Summary:A palladium-catalyzed, environmentally friendly dioxygenation reaction of simple alkenes has been developed that enabled rapid assembly of valuable α-hydroxy ketones with high atom economy. Notably, control experiments and 18O isotope-labeling experiments established that H2O2 played a dominant dual role in this transformation.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b01228