A systematic review of trends in the selective exclusion of older participant from randomised clinical trials

Highlights • Older participants are frequently excluded from clinical trials meaning research populations can be non-representative of the target patients. • We reviewed the proportion of RCTs with unexplained upper age cut offs over an 18-year period. • Of the total 4341 included, 1168 had an unexp...

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Bibliographic Details
Published in:Archives of gerontology and geriatrics 2017-09, Vol.72, p.99-102
Main Authors: Thake, Miriam, Lowry, Andrew
Format: Article
Language:English
Subjects:
Age Factors
Aged
Ageism
Elderly
Exclusion
Female
Geriatrics
Humans
Internal Medicine
Male
Patient Participation - trends
Randomized control trials
Randomized Controlled Trials as Topic
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Summary:Highlights • Older participants are frequently excluded from clinical trials meaning research populations can be non-representative of the target patients. • We reviewed the proportion of RCTs with unexplained upper age cut offs over an 18-year period. • Of the total 4341 included, 1168 had an unexplained upper age limit (26.9%). • Over the 18-year period there was a limited but statistically significant decrease in the proportion of RCTs with unexplained upper age limits.
ISSN:0167-4943
1872-6976
DOI:10.1016/j.archger.2017.05.017