To Improve Translational Research in Subarachnoid Hemorrhage

[...]cerebrovascular anatomy and collaterals, as well as biological and secondary neuroinflammatory responses to insults, are different between species or strains, causing flawed design, unreliable outcomes, unnecessarily more costs, and experimental animals [7, 9–11]. [...]stroke patients have many...

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Bibliographic Details
Published in:Translational stroke research 2018-02, Vol.9 (1), p.1-3
Main Authors: Suzuki, Hidenori, Nakano, Fumi
Format: Article
Language:English
Subjects:
Bias
Biomedical and Life Sciences
Biomedicine
Blood-brain barrier
Brain research
Cardiology
Clinical trials
Editorial
Experiments
Ischemia
Laboratory animals
Neurology
Neurosciences
Neurosurgery
Sexes
Stroke
Traumatic brain injury
Vascular Surgery
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Summary:[...]cerebrovascular anatomy and collaterals, as well as biological and secondary neuroinflammatory responses to insults, are different between species or strains, causing flawed design, unreliable outcomes, unnecessarily more costs, and experimental animals [7, 9–11]. [...]stroke patients have many comorbidities or vascular risk factors including hypertension, diabetes mellitus, dyslipidemia, cardiac diseases, current smoking, obesity, poor diet, inactivity, high alcohol intake, psychosocial stress and depression, social factors such as marital and residence status (i.e., living alone), and prestroke dysfunction, causing stroke severity [5, 14]. Animal models having these factors are also subjected to different stroke injuries or changes in the structure of the neurovascular unit [14]. [...]the use of young healthy animals causes a barrier for translation of findings to patients, while, in preclinical stroke studies with comorbidities, comorbidity duration and severity as well as housing conditions of the animals used, which potentially influence outcomes, should be reported in details. [...]both EBI and cerebral vasospasm occur in the time frame of 72 h in the mouse or rat model, precluding the dissociation between EBI and cerebral vasospasm-induced or other delayed brain injuries. [...]SAH researchers should understand the advantages and disadvantages of each animal model and choose a suitable model dependent on the research question. [...]we can say that the failed clinical trials could have been predicted and avoided if the review and the meta-analysis had been performed before planning the clinical trials.
ISSN:1868-4483
1868-601X
DOI:10.1007/s12975-017-0546-2