Hemocompatibility of Degrading Polymeric Biomaterials: Degradable Polar Hydrophobic Ionic Polyurethane versus Poly(lactic-co-glycolic) Acid

The use of degradable polymers in vascular tissue regeneration has sparked the need to characterize polymer biocompatibility during degradation. While tissue compatibility has been frequently addressed, studies on polymer hemocompatibility during degradation are limited. The current study evaluated...

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Bibliographic Details
Published in:Biomacromolecules 2017-08, Vol.18 (8), p.2296-2305
Main Authors: Brockman, Kathryne S, Lai, Benjamin F. L, Kizhakkedathu, Jayachandran N, Santerre, J. Paul
Format: Article
Language:English
Subjects:
Blood Platelets - metabolism
Humans
Lactic Acid - chemistry
Lactic Acid - pharmacokinetics
Lactic Acid - pharmacology
Materials Testing
Platelet Adhesiveness - drug effects
Polyglycolic Acid - chemistry
Polyglycolic Acid - pharmacokinetics
Polyglycolic Acid - pharmacology
Polyurethanes - chemistry
Polyurethanes - pharmacokinetics
Polyurethanes - pharmacology
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Summary:The use of degradable polymers in vascular tissue regeneration has sparked the need to characterize polymer biocompatibility during degradation. While tissue compatibility has been frequently addressed, studies on polymer hemocompatibility during degradation are limited. The current study evaluated the differences in hemocompatibility (platelet response, complement activation, and coagulation cascade initiation) between as-made and hydrolyzed poly­(lactic-co-glycolic) acid (PLGA) and degradable polar hydrophobic ionic polyurethane (D-PHI). Platelet activation decreased (in whole blood) and platelet adhesion decreased (in blood without leukocytes) for degraded versus as-made PLGA. D-PHI showed minimal hemocompatibility changes over degradation. Leukocytes played a major role in mediating platelet activation for samples and controls, as well as influencing platelet-polymer adhesion on the degraded materials. This study demonstrates the importance of assessing the blood compatibility of biomaterials over the course of degradation since the associated changes in surface chemistry and physical state could significantly change biomaterial hemocompatibility.
ISSN:1525-7797
1526-4602
DOI:10.1021/acs.biomac.7b00456