Undifferentiated sarcoma of the sphenoid sinus

Abstract Paranasal sinuses sarcomas are rare and no treatments have been established. We report a young-adult case of sphenoid sinus sarcoma treated by carbon-ion radiotherapy. The patient presented with progressive left-sided visual impairment. A tumor was then identified and partial resection by t...

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Bibliographic Details
Published in:Auris, nasus, larynx nasus, larynx, 2018-04, Vol.45 (2), p.388-391
Main Authors: Nagaishi, Masaya, Suzuki, Kensuke, Sugiura, Yoshiki, Takano, Issei, Tanaka, Yoshihiro, Hyodo, Akio
Format: Article
Language:English
Subjects:
Carbon-ion radiotherapy
Otolaryngology
Paranasal tumor
Sarcoma
Skull base
Undifferentiated tumor
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Summary:Abstract Paranasal sinuses sarcomas are rare and no treatments have been established. We report a young-adult case of sphenoid sinus sarcoma treated by carbon-ion radiotherapy. The patient presented with progressive left-sided visual impairment. A tumor was then identified and partial resection by transnasal approach was performed. The resected mass showed typical morphology of mesenchymal tumor, and morphological and molecular analyses ruled out a predominant-differentiation phenotype. The pathological diagnosis was undifferentiated sarcoma. The residual lesion was treated with carbon-ion radiotherapy, and tumor progression was absent for one year. The patient died of the tumor regrowth 20 months after initial diagnosis. Although this case had a poorer outcome compared with cases of the more-common sarcoma types, our experience suggested that carbon-ion radiotherapy is potentially beneficial in unresectable undifferentiated sarcomas cases of sphenoid sinus.
ISSN:0385-8146
1879-1476
DOI:10.1016/j.anl.2017.05.018