A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women Under the Age of 50 Years

• Published in: Clinical breast cancer 2017-11, Vol.17 (7), p.516-525.e6
• Main Authors: Lourenco, Ana P, Benson, Kasey L, Henderson, Meredith C, Silver, Michael, Letsios, Elias, Tran, Quynh, Gordon, Kelly J, Borman, Sherri, Corn, Christa, Mulpuri, Rao, Smith, Wendy, Alpers, Josie, Costantini, Carrie, Rohatgi, Nitin, Yang, Rebecca, Haythem, Ali, Biren, Shah, Morris, Michael, Kass, Fred, Reese, David E
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers, Tumor - blood; Biopsies; Breast Neoplasms - blood; Breast Neoplasms - diagnosis; Breast Neoplasms - diagnostic imaging; Carcinoma in Situ - blood; Carcinoma in Situ - diagnosis; Carcinoma in Situ - diagnostic imaging; Carcinoma, Lobular - blood; Carcinoma, Lobular - diagnosis; Carcinoma, Lobular - diagnostic imaging; Female; Follow-Up Studies; Hematology, Oncology and Palliative Medicine; Humans; Imaging; Liquid biopsy; Mammography - methods; Middle Aged; Multimodal Imaging - methods; Obstetrics and Gynecology; Prognosis; Prospective Studies; Proteome - analysis; Proteomics - methods; Serum proteins; Tumor-associated autoantibodies
• ISSN: 1526-8209; 1938-0666
• DOI: 10.1016/j.clbc.2017.05.004

Micro-Abstract To improve breast cancer diagnosis, 2 prospective clinical trials were conducted to test (n = 351) and validate (n = 210) Videssa Breast. If used in conjunction with imaging, Videssa Breast could have reduced unnecessary biopsies by up to 67%. These results support the joint use of breast imaging and Videssa Breast to better inform clinical decisions for women under age 50.