Aneuploidy identification in pre-B acute lymphoblastic leukemia patients at diagnosis by Multiplex Ligation-dependent Probe Amplification (MLPA)

Highlights • A novel use of all telomeres MLPA to identify aneuploidy in ALL patients • MLPA resulted highly correlated with karyotype and the less correlated with DNA index • MLPA would be useful to detect the most common aneuploidies in pediatric ALL • MLPA can be included as an alternative or com...

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Bibliographic Details
Published in:Leukemia research 2017-08, Vol.59, p.117-123
Main Authors: Vázquez-Reyes, A, Bobadilla-Morales, L, Barba-Barba, C, Macías-Salcedo, G, Serafín-Saucedo, G, Velázquez-Rivera, M.E, Almodóvar-Cuevas, M.C, Márquez-Mora, A, Pimentel-Gutiérrez, H.J, Ortega-de-la-Torre, C, Cruz-Osorio, R.M, Nava-Gervasio, S, Rivera-Vargas, J, Sánchez-Zubieta, F, Corona-Rivera, J.R, Corona-Rivera, A
Format: Article
Language:English
Subjects:
ALL
Aneuploidy
Bone Marrow Examination - methods
Child
Chromosome Aberrations
Cytogenetics
DNA-index
Female
Flow Cytometry
Hematology, Oncology and Palliative Medicine
Humans
Karyotype
Karyotyping
Male
MLPA
Multiplex Polymerase Chain Reaction - methods
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics
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Summary:Highlights • A novel use of all telomeres MLPA to identify aneuploidy in ALL patients • MLPA resulted highly correlated with karyotype and the less correlated with DNA index • MLPA would be useful to detect the most common aneuploidies in pediatric ALL • MLPA can be included as an alternative or complementary technique to solve discordances derived from karyotype or DNA index.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2017.05.022