Patient reported outcomes of autologous fat grafting after breast cancer surgery

• Published in: Breast (Edinburgh) 2017-10, Vol.35, p.14-20
• Main Authors: Brown, A.W.W, Kabir, M, Sherman, K.A, Meybodi, F, French, J.R, Elder, E.B
• Format: Article
• Language: English
• Subjects: Adipose Tissue - transplantation; Adult; Breast cancer; Breast Neoplasms - psychology; Breast Neoplasms - surgery; Breast reconstruction; Fat grafting; Female; Follow-Up Studies; Hematology, Oncology and Palliative Medicine; Humans; Lipofilling; Mastectomy - methods; Mastectomy - psychology; Middle Aged; Patient Reported Outcome Measures; Patient Satisfaction; Transplantation, Autologous - methods; Transplantation, Autologous - psychology; Treatment Outcome
• ISSN: 0960-9776; 1532-3080
• DOI: 10.1016/j.breast.2017.06.006

Abstract Introduction Autologous fat grafting (AFG) can be used as an adjunct in breast cancer surgery to improve contour defects. Few previous studies have assessed patient reported outcomes (PROs) for AFG. This study analysed AFG use and assessed PROs in terms of physical and psychosocial well-being. Materials and methods All patients undergoing AFG were identified from a prospective database and asked to complete the validated BREAST-Q questionnaire and a tool to assess patient-perceived change after AFG (5-point Likert-type scale). Descriptive statistics were computed for all BREAST-Q and perceived change subscales. Independent sample t-tests were conducted to compare scores on each of the BREAST-Q and perceived change subscales by type of breast cancer surgery and radiotherapy status. Results 156 AFG sessions were performed over 4 years on 119 breasts in 88 patients. Fifty-seven patients received AFG after reconstruction and 19 after breast conserving surgery. Forty-six patients (52%) completed the questionnaire. BREAST-Q scores (out of 100) and patient-perceived change after AFG (out of 5) were respectively: 54 and 4.0 for Breast satisfaction, 69 and 3.3 for Physical well-being and 60 and 3.6 for Psychosocial well-being. Radiotherapy status and type of surgery made little difference. Number of AFG procedures positively correlated with perceived improvement. Discussion Autologous fat grafting was associated with improved patient satisfaction despite small volumes transferred. BREAST-Q scores were comparable with previously published series on reconstructive breast surgery. Perceived change after AFG was no different in patients receiving radiotherapy.