Safety, Utility, and Clinical Results of Continuous Intraoperative Electrophysiologic Monitoring in 1.5T iMRI-Guided Surgery

• Published in: World neurosurgery 2017-10, Vol.106, p.198-205
• Main Authors: Breitkopf, Martin, Bisdas, Sotirios, Liebsch, Marina, Behling, Felix, Bender, Benjamin, Tatagiba, Marcos, Roder, Constantin
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Astrocytoma - diagnostic imaging; Astrocytoma - surgery; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - surgery; Child; Child, Preschool; Electrodes; Feasibility Studies; Female; Glioblastoma - diagnostic imaging; Glioblastoma - surgery; Glioma; Glioma - diagnostic imaging; Glioma - surgery; Humans; Intraoperative Care; Intraoperative magnetic resonance imaging; Intraoperative monitoring; Intraoperative Neurophysiological Monitoring; Magnetic Resonance Imaging; Male; Middle Aged; Neurosurgery; Neurosurgical Procedures - methods; Oligodendroglioma - diagnostic imaging; Oligodendroglioma - surgery; Postoperative Complications - epidemiology; Retrospective Studies; Surgery, Computer-Assisted; Young Adult
• ISSN: 1878-8750; 1878-8769
• DOI: 10.1016/j.wneu.2017.06.054

To show that the combined use of intraoperative high-field MRI (iMRI) and electrophysiologic monitoring (IOM) is feasible, safe, and beneficial for patients. The setup, surgical, imaging, and clinical results of 110 patients with eloquent intracranial lesions with the combined use of 1.5T iMRI and IOM were analyzed. 187 iMRI scans were performed with IOM needles in place, resulting in a total experience of using >4000 electrodes in the iMRI. No complication (ferromagnetic or relevant heating/burning of skin) was caused by the combined use of both technologies. Surgically induced severe postoperative sensorimotor deficits were seen in 11.8%. The surgeon's estimation of a “complete resection” proved to be true postoperatively in 90.3%. If the resection was stopped due to worsening of IOM, postoperative MRI revealed residual disease to be located in direct vicinity of eloquence in 27 of 28 cases, but not in other parts of the resection cavity. Of these patients, only 7% (2 of 28) had relevant new deficits after 3 months. In 82 patients (74.5%), the resection was continued after the iMRI scan, whereas in only 18 patients (16.4%) the resection was already completed at this point. The combined use of IOM and 1.5T iMRI is feasible and safe. The complementary use of both technologies might result in more radical resections at comparable surgically induced neurologic deficits. If available and indicated, the combined use of IOM and iMRI should be performed on a routine basis.