Quantification of growth patterns of screen-detected lung cancers: The NELSON study

Highlights • Exponential growth is assumed for lung cancer but has never been quantified in-vivo. • Growth patterns of 47 screen-detected solid lung cancers were quantified. • Lung cancer growth could be described by an exponential function with excellent fit. • Therefore, volume-doubling time can b...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-06, Vol.108, p.48-54
Main Authors: Heuvelmans, Marjolein A., MD PhD, Vliegenthart, Rozemarijn, MD PhD, de Koning, Harry J., MD PhD, Groen, Harry J.M., MD PhD, van Putten, Michel J.A.M., MD PhD, Yousaf-Khan, A.U., MD, Weenink, Carla, MD, Nackaerts, Kristiaan, MD PhD, de Jong, Pim A., MD PhD, Oudkerk, Matthijs, MD PhD
Format: Article
Language:English
Subjects:
Adult
Aged
Disease Progression
Early Detection of Cancer - methods
Female
Follow-Up Studies
Growth charts
Hematology, Oncology and Palliative Medicine
Humans
Lung neoplasms
Lung Neoplasms - diagnosis
Lung Neoplasms - epidemiology
Lung Neoplasms - pathology
Male
Mass Screening
Middle Aged
Neoplasm Staging
Netherlands - epidemiology
Pulmonary nodule
Pulmonary/Respiratory
Solitary Pulmonary Nodule - diagnosis
Solitary Pulmonary Nodule - pathology
Time Factors
Tomography, X-Ray Computed
Tumor Burden
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Summary:Highlights • Exponential growth is assumed for lung cancer but has never been quantified in-vivo. • Growth patterns of 47 screen-detected solid lung cancers were quantified. • Lung cancer growth could be described by an exponential function with excellent fit. • Therefore, volume-doubling time can be used to describe growth of pulmonary nodules.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2017.02.021