Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT‐A37

On the basis of the one strain–many compounds strategy, five compounds including two new holomycin derivatives 2 – 3, two new cyclopropaneacetic acid derivatives 4 – 5, together with one known compound holomycin (1) were isolated from a marine‐derived bacterium Streptomyces sp. DT‐A37. Their structu...

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Bibliographic Details
Published in:Chemistry & biodiversity 2017-09, Vol.14 (9), p.n/a
Main Authors: Ding, Hui, Wang, Jia‐Nan, Zhang, Da‐Shan, Ma, Zhong‐Jun
Format: Article
Language:English
Subjects:
Acids
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antimicrobial activity
Bacteria - drug effects
Bacterial Infections - drug therapy
Biological activities
Candida - drug effects
Candidiasis - drug therapy
Cell Line
Cyclopropanes - chemistry
Cyclopropanes - pharmacology
Cytotoxicity
Derivatives
E coli
Fatty acids
Humans
Lactams - chemistry
Lactams - pharmacology
Magnetic Resonance Spectroscopy
NMR
Nuclear magnetic resonance
Nuclear Proteins - antagonists & inhibitors
OSMAC Strategy
Spectrometry, Mass, Electrospray Ionization
Streptomyces - chemistry
Streptomyces sp. DT‐A37
Sulfur heterocycles
Toxicity
Transcription Factors - antagonists & inhibitors
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Summary:On the basis of the one strain–many compounds strategy, five compounds including two new holomycin derivatives 2 – 3, two new cyclopropaneacetic acid derivatives 4 – 5, together with one known compound holomycin (1) were isolated from a marine‐derived bacterium Streptomyces sp. DT‐A37. Their structures were elucidated using NMR and HR‐ESI‐MS analyses. All these compounds were evaluated for their antimicrobial activity, cytotoxic activity, and inhibitory activity against BRD4 protein. Compound 1 exhibited potent cytotoxicity against H1975 cells with IC50 value of 1 μm, and its minimal inhibitory concentration values against Escherichia coli and Staphylococcus aureus were both 64 μm.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201700140