Can the co-dependence of the immune system and angiogenesis facilitate pharmacological targeting of tumours?

Highlights • Immune cells are involved in cancer angiogenesis. • There are numerous molecular mechanisms by which immune cells effect angiogenesis. • Some of these molecular mechanisms can be targeted that could aid in both therapy and prevention. • Targeting angiogenesis can enhance the effects of...

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Bibliographic Details
Published in:Current opinion in pharmacology 2017-08, Vol.35, p.66-74
Main Authors: Mortara, Lorenzo, Benest, Andrew V, Bates, David O, Noonan, Douglas M
Format: Article
Language:English
Subjects:
Animals
Humans
Internal Medicine
Lymphocytes - immunology
Medical Education
Myeloid Cells - immunology
Neoplasms - drug therapy
Neoplasms - immunology
Neoplasms - pathology
Neovascularization, Pathologic - drug therapy
Neovascularization, Pathologic - immunology
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Summary:Highlights • Immune cells are involved in cancer angiogenesis. • There are numerous molecular mechanisms by which immune cells effect angiogenesis. • Some of these molecular mechanisms can be targeted that could aid in both therapy and prevention. • Targeting angiogenesis can enhance the effects of immunotherapy.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2017.05.009