STUDY OF CYTOTOXIC ACTIVITY OF METHANOL EXTRACTS OF THE ENDEMIC PLANT OF THE GENUS ERYSIMUM OF THE ADJARIAN FLORISTIC DISTRICT OF GEORGIA

According to the results, investigated methanolic extracts of endemic plant from Adjarian floristic region of Georgia do not have specific cytotoxicity against the cell lines of breast adenocarcinoma MCF-7 human, which is typical, e.g., for plant pigment curcumin. At the same time, the high specific...

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Bibliographic Details
Published in:Georgian medical news 2017-05 (266), p.80-85
Main Authors: Beridze, D, Metreveli, M, Joxadze, M, Bakuridze, K, Berashvili, D, Bakuridze, A
Format: Article
Language:Russian
Subjects:
Antineoplastic Agents, Phytogenic - pharmacology
Cell Line
Cytotoxins - pharmacology
Erysimum - chemistry
Georgia (Republic)
Humans
Keratinocytes - cytology
Keratinocytes - drug effects
MCF-7 Cells
Methanol
Plant Extracts - pharmacology
Solvents
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Summary:According to the results, investigated methanolic extracts of endemic plant from Adjarian floristic region of Georgia do not have specific cytotoxicity against the cell lines of breast adenocarcinoma MCF-7 human, which is typical, e.g., for plant pigment curcumin. At the same time, the high specific cytotoxicity of 2 and 3 fractions towards keratinocytes gives reason for considering endemic plant extracts, of Adjarian floristic region of Georgia, as a potential pharmacological means for topical treatment of pathologies caused by increased proliferation of keratinocytes, such as psoriasis.
ISSN:1512-0112