P44Apolipoprotein b gene as risk marker of dyslipidemia for teenagers with essential hypertension

BackgroundHypercholesterolemia (HCH) takes a significant position in the progression of total cardiovascular risk. Risk prediction of hypercholesterolemia is necessary in the early stages of ontogeny, in childhood, in cardiovascular disease onset. Genetic predisposition plays an important role in th...

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Bibliographic Details
Published in:Archives of disease in childhood 2017-06, Vol.102 (Suppl 2), p.A51-A52
Main Authors: Olga, Kaluzhnaya, Lyubov, Rychkova, Tatyana, Bairova, Olga, Bugun, Lyubov, Kolesnikova
Format: Article
Language:English
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Summary:BackgroundHypercholesterolemia (HCH) takes a significant position in the progression of total cardiovascular risk. Risk prediction of hypercholesterolemia is necessary in the early stages of ontogeny, in childhood, in cardiovascular disease onset. Genetic predisposition plays an important role in this progression.Research goalTo define the role of insertion-deletion polymorphism (Ins/Del) Apolipoprotein B gene in the lipid disorders formation in teenagers with essential hypertension (EH).MethodsIn total 182 Caucasian teenagers (Russia, Irkutsk) aged 12-18 years (15,52 plus or minus 1,25 years: 109 males and 73 females) were included in the study. The first group: 70 teenagers diagnosed with EH with no hypercholesterolemia (EH-HCH). The second group: 39 teenagers EH+HCH. The control group included 73 teenagers with arterial pressure levels
ISSN:0003-9888
DOI:10.1136/archdischild-2017-313273.132