FOXO transcription factors at the interface of metabolism and cancer

Diabetes refers to a group of metabolic diseases characterized by impaired insulin signalling and high blood glucose. A growing body of epidemiological evidence links diabetes to several types of cancer but the underlying molecular mechanisms are poorly understood. The signalling cascade connecting...

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Bibliographic Details
Published in:International journal of cancer 2017-12, Vol.141 (12), p.2379-2391
Main Authors: Link, Wolfgang, Fernandez‐Marcos, Pablo J.
Format: Article
Language:English
Subjects:
Animals
Blood glucose
Cancer
Cell Proliferation
Cell Survival
Cellular manufacture
Cellular stress response
Deregulation
Diabetes
Diabetes mellitus
Diabetes Mellitus - genetics
Diabetes Mellitus - metabolism
Forkhead protein
Forkhead Transcription Factors - metabolism
Gene expression
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Homeostasis
Humans
Hyperglycemia
Insulin
Insulin - metabolism
Insulin resistance
Medical research
Metabolic disorders
Metabolism
Molecular modelling
Neoplasms - complications
Neoplasms - metabolism
Oxidation resistance
Oxidative Stress
Proteins
Signal Transduction
Transcription factors
Tumors
Viability
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Summary:Diabetes refers to a group of metabolic diseases characterized by impaired insulin signalling and high blood glucose. A growing body of epidemiological evidence links diabetes to several types of cancer but the underlying molecular mechanisms are poorly understood. The signalling cascade connecting insulin and FOXO proteins provides a compelling example for a conserved pathway at the interface between insulin signalling and cancer. FOXOs are transcription factors that orchestrate programs of gene expression known to control a variety of processes in response to cellular stress. Genes regulated by this family of proteins are involved in the regulation of cellular energy production, oxidative stress resistance and cell viability and proliferation. Accordingly, FOXO factors have been shown to play an important role in the suppression of tumour growth and in the regulation of metabolic homeostasis. There is emerging evidence that deregulation of FOXO factors might account for the association between insulin resistance‐related metabolic disorders and cancer.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.30840