Cryptococcus neoformans and gattii promote DNA damage in human peripheral blood mononuclear cells

Cryptococcosis, a systemic mycosis capable of disseminating to the central nervous system with frequent lethal effects, is caused by the species Cryptococus neoformans and Cryptococcus gattii. Several infectious agents such as virus, bacteria, and parasites may be associated to DNA damage and carcin...

Full description

Saved in:
Bibliographic Details
Published in:Medical mycology (Oxford) 2018-04, Vol.56 (3), p.344-349
Main Authors: Andrade, Jéssica Cristina Bilizario Noguerol, Gatto, Mariana, Rodrigues, Daniela Ramos, Soares, Ângela Maria Victoriano de Campos, Calvi, Sueli Aparecida
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cells, Cultured
Cryptococcus gattii - physiology
Cryptococcus neoformans - physiology
DNA Damage
Female
Humans
Leukocytes, Mononuclear - metabolism
Leukocytes, Mononuclear - microbiology
Leukocytes, Mononuclear - pathology
Male
Nitric Oxide - metabolism
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cryptococcosis, a systemic mycosis capable of disseminating to the central nervous system with frequent lethal effects, is caused by the species Cryptococus neoformans and Cryptococcus gattii. Several infectious agents such as virus, bacteria, and parasites may be associated to DNA damage and carcinogenesis in humans. Products of the oxidative metabolism, such as NO, produced as a host defense mechanism to destroy these pathogens, have been implicated in this damage process, due to excessive production related to an established chronic inflammatory response. Here, we investigated whether C. neoformans and /or C. gattii can cause DNA damage in human peripheral blood mononuclear cells (PBMCs) and whether this process is related to NO levels produced by PBMCs. We found that both species are equally able to induce genotoxicity in PBMCs. However, an association between DNA damage and high NO levels was only detected in relation to C. gattii. The results point to the possibility that patients with cryptococcosis are more susceptible to the development of other diseases.
ISSN:1369-3786
1460-2709
DOI:10.1093/mmy/myx046