Hepatocellular carcinoma in South America: Evaluation of risk factors, demographics and therapy

Background & Aims Hepatocellular carcinoma (HCC) is the second leading cause of cancer‐related death worldwide. Most studies addressing the epidemiology of HCC originate from developed countries. This study reports the preliminary findings of a multinational approach to characterize HCC in South...

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Published in:Liver international 2018-01, Vol.38 (1), p.136-143
Main Authors: Debes, Jose D., Chan, Aaron J., Balderramo, Domingo, Kikuchi, Luciana, Gonzalez Ballerga, Esteban, Prieto, Jhon E., Tapias, Monica, Idrovo, Victor, Davalos, Milagros B., Cairo, Fernando, Barreyro, Fernando J., Paredes, Sebastian, Hernandez, Nelia, Avendaño, Karla, Diaz Ferrer, Javier, Yang, Ju Dong, Carrera, Enrique, Garcia, Jairo A., Mattos, Angelo Z., Hirsch, Bruno S., Gonçalves, Pablo T., Carrilho, Flair J., Roberts, Lewis R.
Format: Article
Language:English
Subjects:
Age
Cirrhosis
Demographics
Demography
Developed countries
Diagnosis
Epidemiology
Health risk assessment
Hepatitis
Hepatitis B
Hepatitis C
Hepatocellular carcinoma
Infections
Liver
Liver cancer
Liver cirrhosis
Liver transplantation
Patients
Risk analysis
Risk factors
South America
Surveillance
Therapy
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Summary:Background & Aims Hepatocellular carcinoma (HCC) is the second leading cause of cancer‐related death worldwide. Most studies addressing the epidemiology of HCC originate from developed countries. This study reports the preliminary findings of a multinational approach to characterize HCC in South America. Methods We evaluated 1336 HCC patients seen at 14 centres in six South American countries using a retrospective study design with participating centres completing a template chart of patient characteristics. The diagnosis of HCC was made radiographically or histologically for all cases according to institutional standards. Methodology of surveillance for each centre was following AASLD or EASL recommendations. Results Sixty‐eight percent of individuals were male with a median age of 64 years at time of diagnosis. The most common risk factor for HCC was hepatitis C infection (HCV, 48%), followed by alcoholic cirrhosis (22%), Hepatitis B infection (HBV, 14%) and NAFLD (9%). We found that among individuals with HBV‐related HCC, 38% were diagnosed before age 50. The most commonly provided therapy was transarterial chemoembolization (35% of HCCs) with few individuals being considered for liver transplant (
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.13502