First environmental sample containing plasmid‐mediated colistin‐resistant ESBL‐producing Escherichia coli detected in Norway

We hereby report the detection of the plasmid borne mcr‐1 gene conferring colistin resistance in an extended‐spectrum β‐lactamase (ESBL) producing Escherichia coli ST10 strain retrieved from seawater at a public beach in Norway. The sample was collected in September 2010 and was investigated by whol...

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Bibliographic Details
Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2017-09, Vol.125 (9), p.822-825
Main Authors: Jørgensen, Silje Bakken, Søraas, Arne, Arnesen, Lotte Stenfors, Leegaard, Truls, Sundsfjord, Arnfinn, Jenum, Pål A.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
antibiotic resistance
beta-Lactamases - biosynthesis
beta-Lactamases - genetics
Colistin
Colistin - pharmacology
Drug Resistance, Multiple, Bacterial - genetics
E coli
Escherichia coli - drug effects
Escherichia coli - enzymology
Escherichia coli - genetics
Escherichia coli - isolation & purification
Escherichia coli Proteins - genetics
Genome, Bacterial - genetics
Genomes
Humans
mcr‐1
Microbial Sensitivity Tests
multidrug resistance
Norway
one health
Plasmids - genetics
ST10
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Summary:We hereby report the detection of the plasmid borne mcr‐1 gene conferring colistin resistance in an extended‐spectrum β‐lactamase (ESBL) producing Escherichia coli ST10 strain retrieved from seawater at a public beach in Norway. The sample was collected in September 2010 and was investigated by whole‐genome sequencing in 2016. This report illustrates that E. coli strains carrying plasmid‐mediated colistin resistance genes have also reached areas where this drug is hardly used at all. Surveillance of colistin resistance in environmental, veterinary, and human strains is warranted also in countries where colistin resistance is rare in clinical settings.
ISSN:0903-4641
1600-0463
DOI:10.1111/apm.12720