Left atrial structure and function in cardiac amyloidosis

Abstract Aims Although cardiac amyloidosis (CA) is characterized by significant left atrial (LA) dilatation, the characteristics of LA function remain to be fully investigated. Methods and results We assessed LA function by speckle-tracking echocardiography in 124 patients with CA and sinus rhythm:...

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Bibliographic Details
Published in:European heart journal cardiovascular imaging 2017-10, Vol.18 (10), p.1128-1137
Main Authors: Nochioka, Kotaro, Quarta, Candida Cristina, Claggett, Brian, Roca, Gabriela Querejeta, Rapezzi, Claudio, Falk, Rodney H, Solomon, Scott D
Format: Article
Language:English
Subjects:
Aged
Amyloidosis - diagnostic imaging
Amyloidosis - physiopathology
Atrial Function, Left
Cardiomyopathies - diagnostic imaging
Cardiomyopathies - physiopathology
Case-Control Studies
Disease Progression
Echocardiography, Doppler - methods
Europe
Female
Heart Atria - diagnostic imaging
Humans
Image Interpretation, Computer-Assisted
Internationality
Male
Middle Aged
Prognosis
Reference Values
Retrospective Studies
Risk Assessment
Stroke Volume - physiology
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Summary:Abstract Aims Although cardiac amyloidosis (CA) is characterized by significant left atrial (LA) dilatation, the characteristics of LA function remain to be fully investigated. Methods and results We assessed LA function by speckle-tracking echocardiography in 124 patients with CA and sinus rhythm: 68 with light chain (AL), 29 with mutant (ATTRm), 27 with wild-type (ATTRwt) transthyretin amyloidosis. Conventional and strain-derived parameters, including LA peak longitudinal strain (LS) and strain rate (peak LSR: reservoir function; early LSR: conduit function; late LSR: active function), were assessed compared between CA patients and 20 healthy controls of similar age and gender. All LA function phases, including LA longitudinal strain, peak LSR, early and late LSR were significantly impaired in CA compared to healthy controls after adjusting for LA size, LV ejection fraction and LV filling pressures (E/E’) (all P 
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jex097