Synthesis of substituted 2H-chromenes by a three-component reaction as potential antioxidants

A series of alkoxy-substituted 2 H -chromenes were synthesized by a one-pot three-component reaction using salicylaldehydes, acetyl acetone and alcohol as reactant and medium with tetra-n-butylammonium fluoride (TBAF) as catalyst. Simple reaction conditions, short reaction time and overall good yiel...

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Bibliographic Details
Published in:Molecular diversity 2017-11, Vol.21 (4), p.841-848
Main Authors: Subbareddy, Chitreddy V., Subashini, Radhakrishnan, Sumathi, Shanmugam
Format: Article
Language:English
Subjects:
Acetone
Alcohols
Antioxidants
Antioxidants - chemical synthesis
Antioxidants - chemistry
Benzopyrans - chemical synthesis
Benzopyrans - chemistry
Biochemistry
Biomedical and Life Sciences
Biphenyl Compounds - chemistry
Chemical compounds
Chemical reactions
Chemical synthesis
Chemistry Techniques, Synthetic
Life Sciences
Molecular structure
Organic Chemistry
Original Article
Pharmacy
Picrates - chemistry
Polymer Sciences
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Summary:A series of alkoxy-substituted 2 H -chromenes were synthesized by a one-pot three-component reaction using salicylaldehydes, acetyl acetone and alcohol as reactant and medium with tetra-n-butylammonium fluoride (TBAF) as catalyst. Simple reaction conditions, short reaction time and overall good yield of products make this synthetic strategy an efficient one to synthesize 2 H -chromene molecules. All the synthesized compounds were evaluated for antioxidant activities. Among all the new compounds, 5j and 5k showed good inhibition ( 70.41 ± 0.14 and 64.71 ± 1.02 % ) at 100 μ g/mL concentrations.
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-017-9758-3