Free-Radical-Promoted Copper-Catalyzed Decarboxylative Alkylation of α,β-Unsaturated Carboxylic Acids with ICH2CF3 and Its Analogues

A novel and efficient free-radical-promoted copper-catalyzed decarboxylative alkylation of α,β-unsaturated carboxylic acids with ICH2CF3 and its analogues has been developed. This methodology provides a convenient access to the synthesis of allylic trifluoromethyl and β-CF3 ketone containing compoun...

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Bibliographic Details
Published in:Journal of organic chemistry 2017-07, Vol.82 (14), p.7428-7436
Main Authors: Zhu, Yan, Gong, Juwen, Wang, Yonghui
Format: Article
Language:English
Online Access:Get full text
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Summary:A novel and efficient free-radical-promoted copper-catalyzed decarboxylative alkylation of α,β-unsaturated carboxylic acids with ICH2CF3 and its analogues has been developed. This methodology provides a convenient access to the synthesis of allylic trifluoromethyl and β-CF3 ketone containing compounds as well as other biologically useful fluorinated molecules and materials.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b01107