Anticancer potential of sanguinarine for various human malignancies

Sanguinarine (Sang) - a benzophenanthridine alkaloid extracted from - exhibits antioxidant, anti-inflammatory, proapoptotic and growth inhibitory activities on tumor cells of various cancer types as established by and studies. Although the underlying mechanism of Sang antitumor activity is yet to be...

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Bibliographic Details
Published in:Future medicinal chemistry 2017-06, Vol.9 (9), p.933-950
Main Authors: Achkar, Iman W, Mraiche, Fatima, Mohammad, Ramzi M, Uddin, Shahab
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Benzophenanthridines - chemistry
Benzophenanthridines - pharmacology
cancer
Cell Death - drug effects
Cell Proliferation - drug effects
Drug Screening Assays, Antitumor
Humans
Isoquinolines - chemistry
Isoquinolines - pharmacology
molecular targets
natural compounds
proapoptotic
Sanguinarine
Signal Transduction - drug effects
Structure-Activity Relationship
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Summary:Sanguinarine (Sang) - a benzophenanthridine alkaloid extracted from - exhibits antioxidant, anti-inflammatory, proapoptotic and growth inhibitory activities on tumor cells of various cancer types as established by and studies. Although the underlying mechanism of Sang antitumor activity is yet to be fully elucidated, Sang has displayed multiple biological effects, which remain to suggest its possible use in plant-derived treatments of human malignancies. This review covers the anticancer abilities of Sang including inhibition of aberrantly activated signal transduction pathways, induction of cell death and inhibition of cancer cell proliferation. It also highlights Sang-mediated inhibition of angiogenesis, inducing the expression of tumor suppressors, sensitization of cancer cells to standard chemotherapeutics to enhance their cytotoxic effects, while addressing the present need for further pharmacokinetic-based studies.
ISSN:1756-8919
1756-8927
DOI:10.4155/fmc-2017-0041