Joint loading and proximal tibia subchondral trabecular bone microarchitecture differ with walking gait patterns in end-stage knee osteoarthritis

Summary Objectives To (1) stratify subgroups according to their distinct walking gait patterns in end-stage knee osteoarthritis (OA) patients; (2) compare measures of joint loading and proximal tibia subchondral trabecular bone (STB) microarchitecture among subgroups. Design Twenty-five knee OA pati...

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Bibliographic Details
Published in:Osteoarthritis and cartilage 2017-10, Vol.25 (10), p.1623-1632
Main Authors: Roberts, Bryant C, Solomon, Lucian B, Mercer, Graham, Reynolds, Karen J, Thewlis, Dominic, Perilli, Egon
Format: Article
Language:English
Subjects:
Gait biomechanics
Gait phenotypes
Knee osteoarthritis
Micro-CT
Rheumatology
Subchondral trabecular bone Microarchitecture
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Summary:Summary Objectives To (1) stratify subgroups according to their distinct walking gait patterns in end-stage knee osteoarthritis (OA) patients; (2) compare measures of joint loading and proximal tibia subchondral trabecular bone (STB) microarchitecture among subgroups. Design Twenty-five knee OA patients undergoing total knee arthroplasty had pre-operative gait analysis. Following surgery, excised tibial plateaus were micro-CT-scanned and STB microarchitecture analysed in four tibial condylar regions of interest. Peak knee moments were input to k-means cluster analysis, to identify subgroups with homogeneous gait patterns. Joint loading and STB microarchitecture parameters were compared among gait subgroups (Kruskal-Wallis, Bonferroni-corrected Mann-Whitney-U-tests). Results Three gait subgroups were revealed: biphasics (n=7), flexors (n=9), counter-rotators (n=9). Peak knee adduction moment (KAM) and KAM impulse were significantly higher (p
ISSN:1063-4584
1522-9653
DOI:10.1016/j.joca.2017.06.001