Reconfiguration of DNA molecular arrays driven by information relay

Information relay at the molecular level is an essential phenomenon in numerous chemical and biological processes, such as intricate signaling cascades. One key challenge in synthetic molecular self-assembly is to construct artificial structures that imitate these complex behaviors in controllable s...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2017-07, Vol.357 (6349), p.371-371
Main Authors: Song, Jie, Li, Zhe, Wang, Pengfei, Meyer, Travis, Mao, Chengde, Ke, Yonggang
Format: Article
Language:English
Subjects:
Arrays
Aspect ratio
Atomic force microscopy
Base stacking
Binding
Biological activity
Cascades
Chemical stimuli
Complexity
Configurations
Conformation
Construction
Construction materials
Cues
Decoupling
Deoxyribonucleic acid
Design
DNA
DNA - chemistry
Gel electrophoresis
Gene sequencing
High temperature
Hybridization
Information dissemination
Information Technology
Kinetics
Microscopy
Modular structures
Modular units
Molecular interactions
Nanostructure
Nanotechnology - methods
Nicking endonuclease
Nucleic Acid Conformation
Nucleotide sequence
Oligonucleotide Array Sequence Analysis - methods
Propagation
Reconfiguration
Relay
RESEARCH ARTICLE SUMMARY
Self-assembly
Stability
Strands
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Summary:Information relay at the molecular level is an essential phenomenon in numerous chemical and biological processes, such as intricate signaling cascades. One key challenge in synthetic molecular self-assembly is to construct artificial structures that imitate these complex behaviors in controllable systems. We demonstrated prescribed, long-range information relay in an artificial molecular array assembled from modular DNA structural units. The dynamic DNA molecular array exhibits transformations with programmable initiation, propagation, and regulation. The transformation of the array can be initiated at selected units and then propagated, without addition of extra triggers, to neighboring units and eventually the entire array. The specific information pathways by which this transformation occurs can be controlled by altering the design of individual units and the arrays.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aan3377