Heterogeneous Microtesla SABRE Enhancement of 15 N NMR Signals

The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadien...

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Published in:Angewandte Chemie International Edition 2017-08, Vol.56 (35), p.10433-10437
Main Authors: Kovtunov, Kirill V, Kovtunova, Larisa M, Gemeinhardt, Max E, Bukhtiyarov, Andrey V, Gesiorski, Jonathan, Bukhtiyarov, Valerii I, Chekmenev, Eduard Y, Koptyug, Igor V, Goodson, Boyd M
Format: Article
Language:English
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Summary:The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET-SABRE) catalyst that was used to demonstrate a circa 100-fold enhancement of N NMR signals in N-pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XPS characterization supports the fact that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst-free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201705014