Antibacterial Effect of Genetically-Engineered Bacteriophage ϕEf11/ϕFL1C(Δ36)PnisA on Dentin Infected with Antibiotic-Resistant Enterococcus faecalis

Highlights • Treatment of E. faecalis- infected dentin with bacteriophage ϕEf11/ϕFL1C(Δ36)PnisA resulted in a decrease in the residual bacterial population. • Both vancomycin-sensitive and resistant E. faecalis strains were disrupted by infection with bacteriophage. • The recovered E. faecalis titer...

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Bibliographic Details
Published in:Archives of oral biology 2017-10, Vol.82, p.166-170
Main Authors: Tinoco, Justine Monnerat, Liss, Nadia, Zhang, Hongming, Nissan, Roni, Gordon, Wanda, Tinoco, Eduardo, Sassone, Luciana, Stevens, Roy
Format: Article
Language:English
Subjects:
Advanced Basic Science
Antimicrobial
Bacteriophage
Dentin infection
Dentistry
Enterococcus faecalis phage therapy
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Summary:Highlights • Treatment of E. faecalis- infected dentin with bacteriophage ϕEf11/ϕFL1C(Δ36)PnisA resulted in a decrease in the residual bacterial population. • Both vancomycin-sensitive and resistant E. faecalis strains were disrupted by infection with bacteriophage. • The recovered E. faecalis titer was reduced by 18% for the JH2-2 infected models, and by 99% for the V583 infected models.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2017.06.005