Antibacterial Effect of Genetically-Engineered Bacteriophage ϕEf11/ϕFL1C(Δ36)PnisA on Dentin Infected with Antibiotic-Resistant Enterococcus faecalis

Highlights • Treatment of E. faecalis- infected dentin with bacteriophage ϕEf11/ϕFL1C(Δ36)PnisA resulted in a decrease in the residual bacterial population. • Both vancomycin-sensitive and resistant E. faecalis strains were disrupted by infection with bacteriophage. • The recovered E. faecalis titer...

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Published in:Archives of oral biology 2017-10, Vol.82, p.166-170
Main Authors: Tinoco, Justine Monnerat, Liss, Nadia, Zhang, Hongming, Nissan, Roni, Gordon, Wanda, Tinoco, Eduardo, Sassone, Luciana, Stevens, Roy
Format: Article
Language:English
Subjects:
Advanced Basic Science
Antimicrobial
Bacteriophage
Dentin infection
Dentistry
Enterococcus faecalis phage therapy
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container_start_page 166
container_title Archives of oral biology
container_volume 82
creator Tinoco, Justine Monnerat
Liss, Nadia
Zhang, Hongming
Nissan, Roni
Gordon, Wanda
Tinoco, Eduardo
Sassone, Luciana
Stevens, Roy
description Highlights • Treatment of E. faecalis- infected dentin with bacteriophage ϕEf11/ϕFL1C(Δ36)PnisA resulted in a decrease in the residual bacterial population. • Both vancomycin-sensitive and resistant E. faecalis strains were disrupted by infection with bacteriophage. • The recovered E. faecalis titer was reduced by 18% for the JH2-2 infected models, and by 99% for the V583 infected models.
doi_str_mv 10.1016/j.archoralbio.2017.06.005
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subjects Advanced Basic Science
Antimicrobial
Bacteriophage
Dentin infection
Dentistry
Enterococcus faecalis phage therapy
title Antibacterial Effect of Genetically-Engineered Bacteriophage ϕEf11/ϕFL1C(Δ36)PnisA on Dentin Infected with Antibiotic-Resistant Enterococcus faecalis
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