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Is Toxoplasma gondii infection protective against multiple sclerosis risk?

Abstract Background Parasitic infections may play a protective role in neurodegenative diseases. Objectıve To determine the association between Toxoplasma gondii ( T. gondii ) infection and Multiple Sclerosis (MS). Methods One hundred fifteen patients with MS were included in the study. Sixty age an...

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Published in:	Multiple sclerosis and related disorders 2017-07, Vol.15, p.7-10
Main Authors:	Koskderelioglu, Asli, Afsar, Ilhan, Pektas, Bayram, Gedizlioglu, Muhtesem
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Language:	English
Subjects:	Adult Antibodies, Protozoan - immunology Female Humans Hygiene Immunoglobulin G - immunology Male Middle Aged Multiple sclerosis Multiple Sclerosis - blood Multiple Sclerosis - complications Multiple Sclerosis - parasitology Neurology Parasite Risk Factors Toxoplasma gondii Toxoplasmosis - complications Toxoplasmosis - immunology Toxoplasmosis - parasitology
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description	Abstract Background Parasitic infections may play a protective role in neurodegenative diseases. Objectıve To determine the association between Toxoplasma gondii ( T. gondii ) infection and Multiple Sclerosis (MS). Methods One hundred fifteen patients with MS were included in the study. Sixty age and gender-matched healthy subjects were recruited as controls. Subjects were assessed for clinical and demographic parameters. The presence of specific IgG antibodies against T. gondii microorganism was searched by using an enzyme immunoassay test in the sera of the subjects. Results T. gondii seropositivity was found to be lower in MS patients than in healthy controls (33.9% vs. 55%, p=0.007). Mean age and disease duration of the patients were 41.15±11.20 (18–74) and 1.90±1.44 (0–6) years, respectively. MS patients with a high IgG titer had lower expanded disability status scale (EDSS) scores (p=0.001) and lower annualized relapse rates (ARR) (p=0.005). There was no significant association between T. gondii seropositivity and disease duration (p=0.598). Female MS patients tended to have higher T. gondii seropositivity than males although the difference did not reach statistical significance (p=0.192). We found a negative correlation between T. gondii seropositivity and both EDSS scores (r=−0.322, p
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Objectıve To determine the association between Toxoplasma gondii ( T. gondii ) infection and Multiple Sclerosis (MS). Methods One hundred fifteen patients with MS were included in the study. Sixty age and gender-matched healthy subjects were recruited as controls. Subjects were assessed for clinical and demographic parameters. The presence of specific IgG antibodies against T. gondii microorganism was searched by using an enzyme immunoassay test in the sera of the subjects. Results T. gondii seropositivity was found to be lower in MS patients than in healthy controls (33.9% vs. 55%, p=0.007). Mean age and disease duration of the patients were 41.15±11.20 (18–74) and 1.90±1.44 (0–6) years, respectively. MS patients with a high IgG titer had lower expanded disability status scale (EDSS) scores (p=0.001) and lower annualized relapse rates (ARR) (p=0.005). There was no significant association between T. gondii seropositivity and disease duration (p=0.598). Female MS patients tended to have higher T. gondii seropositivity than males although the difference did not reach statistical significance (p=0.192). We found a negative correlation between T. gondii seropositivity and both EDSS scores (r=−0.322, p<0.001) and ARR (r=−0.263, p=0.004). Conclusıon We found a negative association between T. gondii infection and the presence of MS. Furthermore, parasite infected MS patients had experienced fewer relapses with lower disability scores supporting the hypothesis of immunomodulatory effects of parasitic infections in autoimmune diseases. Further studies are required to establish the protective role of parasitic infections in MS.</description><identifier>ISSN: 2211-0348</identifier><identifier>EISSN: 2211-0356</identifier><identifier>DOI: 10.1016/j.msard.2017.04.004</identifier><identifier>PMID: 28641775</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Antibodies, Protozoan - immunology ; Female ; Humans ; Hygiene ; Immunoglobulin G - immunology ; Male ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis - blood ; Multiple Sclerosis - complications ; Multiple Sclerosis - parasitology ; Neurology ; Parasite ; Risk Factors ; Toxoplasma gondii ; Toxoplasmosis - complications ; Toxoplasmosis - immunology ; Toxoplasmosis - parasitology</subject><ispartof>Multiple sclerosis and related disorders, 2017-07, Vol.15, p.7-10</ispartof><rights>Elsevier B.V.</rights><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-873d3a2d20f478e9d5c7d260c38ea1dee32633078c1b1f302f7582155e2a7b763</citedby><cites>FETCH-LOGICAL-c414t-873d3a2d20f478e9d5c7d260c38ea1dee32633078c1b1f302f7582155e2a7b763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28641775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koskderelioglu, Asli</creatorcontrib><creatorcontrib>Afsar, Ilhan</creatorcontrib><creatorcontrib>Pektas, Bayram</creatorcontrib><creatorcontrib>Gedizlioglu, Muhtesem</creatorcontrib><title>Is Toxoplasma gondii infection protective against multiple sclerosis risk?</title><title>Multiple sclerosis and related disorders</title><addtitle>Mult Scler Relat Disord</addtitle><description>Abstract Background Parasitic infections may play a protective role in neurodegenative diseases. Objectıve To determine the association between Toxoplasma gondii ( T. gondii ) infection and Multiple Sclerosis (MS). Methods One hundred fifteen patients with MS were included in the study. Sixty age and gender-matched healthy subjects were recruited as controls. Subjects were assessed for clinical and demographic parameters. The presence of specific IgG antibodies against T. gondii microorganism was searched by using an enzyme immunoassay test in the sera of the subjects. Results T. gondii seropositivity was found to be lower in MS patients than in healthy controls (33.9% vs. 55%, p=0.007). Mean age and disease duration of the patients were 41.15±11.20 (18–74) and 1.90±1.44 (0–6) years, respectively. MS patients with a high IgG titer had lower expanded disability status scale (EDSS) scores (p=0.001) and lower annualized relapse rates (ARR) (p=0.005). There was no significant association between T. gondii seropositivity and disease duration (p=0.598). Female MS patients tended to have higher T. gondii seropositivity than males although the difference did not reach statistical significance (p=0.192). We found a negative correlation between T. gondii seropositivity and both EDSS scores (r=−0.322, p<0.001) and ARR (r=−0.263, p=0.004). Conclusıon We found a negative association between T. gondii infection and the presence of MS. Furthermore, parasite infected MS patients had experienced fewer relapses with lower disability scores supporting the hypothesis of immunomodulatory effects of parasitic infections in autoimmune diseases. 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Objectıve To determine the association between Toxoplasma gondii ( T. gondii ) infection and Multiple Sclerosis (MS). Methods One hundred fifteen patients with MS were included in the study. Sixty age and gender-matched healthy subjects were recruited as controls. Subjects were assessed for clinical and demographic parameters. The presence of specific IgG antibodies against T. gondii microorganism was searched by using an enzyme immunoassay test in the sera of the subjects. Results T. gondii seropositivity was found to be lower in MS patients than in healthy controls (33.9% vs. 55%, p=0.007). Mean age and disease duration of the patients were 41.15±11.20 (18–74) and 1.90±1.44 (0–6) years, respectively. MS patients with a high IgG titer had lower expanded disability status scale (EDSS) scores (p=0.001) and lower annualized relapse rates (ARR) (p=0.005). There was no significant association between T. gondii seropositivity and disease duration (p=0.598). Female MS patients tended to have higher T. gondii seropositivity than males although the difference did not reach statistical significance (p=0.192). We found a negative correlation between T. gondii seropositivity and both EDSS scores (r=−0.322, p<0.001) and ARR (r=−0.263, p=0.004). Conclusıon We found a negative association between T. gondii infection and the presence of MS. Furthermore, parasite infected MS patients had experienced fewer relapses with lower disability scores supporting the hypothesis of immunomodulatory effects of parasitic infections in autoimmune diseases. Further studies are required to establish the protective role of parasitic infections in MS.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28641775</pmid><doi>10.1016/j.msard.2017.04.004</doi><tpages>4</tpages></addata></record>
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subjects	Adult Antibodies, Protozoan - immunology Female Humans Hygiene Immunoglobulin G - immunology Male Middle Aged Multiple sclerosis Multiple Sclerosis - blood Multiple Sclerosis - complications Multiple Sclerosis - parasitology Neurology Parasite Risk Factors Toxoplasma gondii Toxoplasmosis - complications Toxoplasmosis - immunology Toxoplasmosis - parasitology
title	Is Toxoplasma gondii infection protective against multiple sclerosis risk?
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